| MNPR |
MONOPAR THERAPEUTICS INC |
Common Stock |
20% |
$105,138,701 |
+$9,391,992 |
1,287,368 |
+9.8% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| DRUG |
BRIGHT MINDS BIOSCIENCES INC. |
Common Stock |
15% |
$103,357,513 |
+$924,052 |
1,155,995 |
+0.9% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| CMPR |
CIMPRESS PLC |
Ordinary Shares |
15% |
$284,891,086 |
+$21,424,139 |
3,620,423 |
+8.1% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| SLNO |
SOLENO THERAPEUTICS, INC. |
Common Stock |
13% |
$297,973,475 |
+$46,574,843 |
7,178,354 |
+19% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| CCSI |
Consensus Cloud Solutions, Inc. |
Common Stock |
13% |
$72,729,753 |
-$1,308,933 |
2,476,328 |
-1.8% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| BHVN |
BIOHAVEN LTD. |
Common Shares |
13% |
$189,711,052 |
+$113,253,896 |
16,803,459 |
+148% |
JANUS HENDERSON GROUP PLC |
30 Jan 2026 |
| PRAX |
PRAXIS PRECISION MEDICINES, INC |
Common Stock |
12% |
$146,484,527 |
+$12,214,062 |
2,763,859 |
+9.1% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| CAMP |
CAMP4 THERAPEUTICS CORP |
Common Stock |
12% |
$37,908,892 |
|
6,307,636 |
|
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| ENTA |
ENANTA PHARMACEUTICALS INC |
Common Stock |
12% |
$41,823,994 |
|
3,494,068 |
|
JANUS HENDERSON GROUP PLC |
31 Oct 2025 |
| IVVD |
INVIVYD, INC. |
Common Stock |
12% |
$27,921,385 |
+$1,222,450 |
25,383,077 |
+4.6% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| TVTX |
TRAVERE THERAPEUTICS, INC |
Common Stock |
12% |
$253,331,874 |
-$17,690,876 |
10,599,660 |
-6.5% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| MIRM |
MIRUM PHARAMACEUTICALS, INC. |
Common Stock |
12% |
$479,098,679 |
+$48,995,048 |
6,065,308 |
+11% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| FBRX |
FORTE BIOSCIENCES, INC. |
Common Stock |
11% |
$38,881,157 |
+$20,950,887 |
1,425,785 |
+117% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| WEX |
WEX, Inc. |
Common Stock |
11% |
$568,535,395 |
-$20,251,431 |
3,870,484 |
-3.4% |
JANUS HENDERSON GROUP PLC |
30 Jun 2025 |
| SGRY |
SURGERY PARTNERS, INC. |
Common Stock |
10% |
$282,111,656 |
+$1,767,274 |
13,036,583 |
+0.63% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| PCVX |
VAXCYTE, INC. |
Common Stock |
10% |
$472,013,392 |
-$57,168,819 |
13,104,203 |
-11% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| RLMD |
RELMADA THERAPEUTICS, INC. |
Common Stock |
10% |
$35,932,374 |
|
7,439,415 |
|
JANUS HENDERSON GROUP PLC |
30 Jan 2026 |
| ICUI |
ICU MEDICAL, INC. |
Common Stock |
10% |
$326,429,794 |
+$272,229 |
2,470,146 |
+0.08% |
JANUS HENDERSON GROUP PLC |
30 Jun 2025 |
| TARA |
PROTARA THERAPEUTICS, INC. |
Common Stock |
10% |
$29,564,292 |
+$5,234,139 |
5,141,616 |
+22% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| LXEO |
LEXEO THERAPEUTICS, INC. |
Common Stock |
10% |
$65,914,563 |
+$10,720,599 |
7,291,434 |
+19% |
JANUS HENDERSON GROUP PLC |
28 Nov 2025 |
| BNTC |
BENITEC BIOPHARMA INC. |
Common Stock |
10% |
$44,484,293 |
-$292,158,468 |
3,382,836 |
-87% |
JANUS HENDERSON GROUP PLC |
28 Nov 2025 |
| PALI |
PALISADE BIO, INC. |
Common Stock |
10% |
$27,835,737 |
|
14,885,421 |
|
JANUS HENDERSON GROUP PLC |
28 Nov 2025 |
| INO |
INOVIO PHARMACEUTICALS, INC. |
Common Stock |
10% |
$12,999,275 |
+$6,630,068 |
6,666,295 |
+104% |
JANUS HENDERSON GROUP PLC |
28 Nov 2025 |
| OVID |
OVID THERAPEUTICS INC. |
Common Stock |
10% |
$9,461,772 |
|
7,114,114 |
|
JANUS HENDERSON GROUP PLC |
28 Nov 2025 |
| EQ |
EQUILLIUM, INC. |
Common Stock |
10% |
$9,429,020 |
|
6,083,239 |
0% |
JANUS HENDERSON GROUP PLC |
30 Jan 2026 |
| IMUX |
IMMUNIC, INC. |
Common Stock |
10% |
$8,531,675 |
+$6,622,427 |
12,016,444 |
+347% |
JANUS HENDERSON GROUP PLC |
28 Nov 2025 |
| KTTA |
PASITHEA THERAPEUTICS CORP. |
Common Stock |
10% |
$7,160,756 |
|
10,229,652 |
|
JANUS HENDERSON GROUP PLC |
28 Nov 2025 |
| TENX |
TENAX THERAPEUTICS, INC. |
Common Stock |
10% |
$4,172,774 |
+$3,057,778 |
623,733 |
+274% |
JANUS HENDERSON GROUP PLC |
28 Nov 2025 |
| PTNT |
PALATIN TECHNOLOGIES INC |
Common Stock |
10% |
$1,296,139 |
|
170,097 |
|
JANUS HENDERSON GROUP PLC |
28 Nov 2025 |
| TFX |
TELEFLEX INCORPORATED |
Common Stock |
9.4% |
$496,584,753 |
-$21,152,842 |
4,149,271 |
-4.1% |
JANUS HENDERSON GROUP PLC |
30 Jun 2025 |
| JANX |
JANUX THERAPEUTICS, INC. |
Common Stock |
8.9% |
$73,836,251 |
-$9,432,245 |
5,350,453 |
-11% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| DBVT |
DBV TECHNOLOGIES S.A. |
Common Stock |
8.8% |
|
|
20,469,392 |
+288% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| LNTH |
LANTHEUS HOLDINGS, INC. |
Common Stock |
8.6% |
$385,581,607 |
-$66,039,224 |
5,707,247 |
-15% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| DYN |
DYNE THERAPEUTICS INC |
Common Stock |
8.5% |
$251,645,523 |
-$15,543,028 |
13,887,722 |
-5.8% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| OLMA |
OLEMA PHARMACEUTICALS, INC. |
Common Stock |
8.4% |
$193,186,485 |
+$89,949,893 |
6,710,194 |
+87% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| ZD |
ZIFF DAVIS, INC. |
Common Stock |
8.4% |
$131,029,443 |
-$4,946,066 |
3,439,093 |
-3.6% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| ASMB |
ASSEMBLY BIOSCIENCES, INC. |
Common Stock |
8.2% |
$44,444,160 |
|
1,341,508 |
|
JANUS HENDERSON GROUP PLC |
28 Nov 2025 |
| FDMT |
4D MOLECULAR THERAPEUTICS, INC. |
Common Stock |
8.1% |
$36,437,978 |
+$18,735,371 |
4,635,875 |
+106% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| CTNM |
CONTINEUM THERAPEUTICS, INC. |
Class A Common Stock |
7.9% |
$27,991,830 |
|
2,448,979 |
|
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| ASND |
ASCENDIS PHARMA A/S |
American Depositary Shares |
7.8% |
$859,467,360 |
-$20,821,968 |
4,323,059 |
-2.4% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| GPCR |
STRUCTURE THERAPEUTICS INC |
American Depositary Shares |
7.7% |
$124,567,128 |
-$3,477,040 |
4,448,826 |
-2.7% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| IMMX |
IMMIX BIOPHARMA, INC. |
Common Stock |
7.4% |
$19,098,036 |
|
3,921,568 |
|
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| IDYA |
IDEAYA BIOSCIENCES, INC. |
Common Stock |
7.3% |
$174,915,104 |
+$6,043,368 |
6,428,339 |
+3.6% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| MAZE |
MAZE THERAPEUTICS, INC. |
Common Stock |
7.3% |
$83,143,819 |
+$15,075,261 |
3,206,472 |
+22% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| MDGL |
MADRIGAL PHARMACEUTICALS, INC. |
Common Stock |
7% |
$814,704,393 |
-$132,548,829 |
1,584,843 |
-14% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| ARMK |
ARAMARK |
Common Stock |
6.9% |
$783,751,824 |
+$62,546,703 |
17,963,599 |
+8.7% |
JANUS HENDERSON GROUP PLC |
30 Jun 2025 |
| ST |
SENSATA TECHNOLOGIES HOLDING PLC |
Ordinary Shares |
6.9% |
$307,320,322 |
+$2,666,251 |
10,059,585 |
+0.88% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| RVTY |
REVVITY, INC. |
American Depositary Shares |
6.6% |
$668,529,251 |
+$35,545,406 |
7,627,259 |
+5.6% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| JBIO |
JADE BIOSCIENCES, INC. |
Common Stock |
6.2% |
$42,459,514 |
|
3,063,457 |
|
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| RVMD |
REVOLUTION MEDICINES, INC. |
Common Stock |
6.1% |
$530,327,722 |
+$35,740,771 |
11,356,054 |
+7.2% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| GMED |
GLOBUS MEDICAL, INC. |
Class A Common Stock |
6.1% |
$522,135,958 |
+$30,787,723 |
7,029,294 |
+6.3% |
JANUS HENDERSON GROUP PLC |
31 Mar 2025 |
| ASUR |
ASURE SOFTWARE INC |
Class A Common Stock |
6.1% |
$13,752,294 |
-$316,528 |
1,677,109 |
-2.2% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| FLEX |
FLEX LTD. |
Ordinary Shares |
6% |
$1,387,675,992 |
-$247,217,838 |
22,331,445 |
-15% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| DAY |
DAYFORCE, INC. |
Common Stock |
6% |
$647,420,298 |
+$69,826,973 |
9,397,885 |
+12% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| PTCT |
PTC THERAPEUTICS, INC. |
Common Stock |
6% |
$376,123,770 |
|
4,851,332 |
|
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| OCGN |
OCUGEN, INC. |
Common Stock |
6% |
$26,800,000 |
|
20,000,000 |
|
JANUS HENDERSON GROUP PLC |
28 Nov 2025 |
| OSIS |
OSI SYSTEMS, INC. |
Common Stock |
5.9% |
$249,312,529 |
-$13,068,899 |
1,000,291 |
-5% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| BELFB |
BEL FUSE INC. |
Class B Common Stock |
5.9% |
$116,435,356 |
|
619,337 |
|
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| SSNC |
SS&C TECHNOLOGIES HOLDINGS, INC. |
Common Stock |
5.7% |
$1,246,559,289 |
-$224,048,552 |
14,017,309 |
-15% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| BBIO |
BRIDGEBIO PHARMA, INC. |
Common Stock |
5.7% |
$845,275,116 |
|
11,000,457 |
|
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| GIL |
GILDAN ACTIVEWEAR INC |
Common Stock |
5.7% |
$666,541,832 |
-$114,890 |
10,495,069 |
-0.02% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| ARDX |
ARDELYX, INC. |
Common Stock |
5.7% |
$76,170,752 |
-$6,798,497 |
13,824,093 |
-8.2% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| RTO |
RENTOKIL INITIAL PLC |
Common Stock |
5.6% |
|
-$2,244,147 |
142,436,808 |
-0.31% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| TYRA |
TYRA BIOSCIENCES, INC |
Common Stock |
5.4% |
$29,305,535 |
+$1,672,924 |
2,856,290 |
+6.1% |
JANUS HENDERSON GROUP PLC |
30 Jun 2025 |
| APG |
API GROUP CORP |
Common Stock |
5.3% |
$763,991,448 |
|
22,228,439 |
|
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| GKOS |
GLAUKOS CORP |
Common Stock |
5.3% |
$340,851,240 |
|
3,018,787 |
|
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| LGND |
LIGAND PHARMACEUTICALS INCORPORATED |
Common Stock |
5.3% |
$184,646,839 |
-$3,251,582 |
1,042,378 |
-1.7% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| DKNG |
DRAFTKINGS INC. |
Class A Common Stock |
5.1% |
$884,721,120 |
|
25,313,909 |
|
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| XENE |
XENON PHARMACEUTICALS INC. |
Common Stock |
5.1% |
$158,346,983 |
|
3,943,885 |
|
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| BMEA |
BIOMEA FUSION, INC. |
Common Stock |
5% |
$4,725,000 |
|
3,750,000 |
|
JANUS HENDERSON GROUP PLC |
28 Nov 2025 |
| SXT |
SENSIENT TECHNOLOGIES CORPORATION |
Common Stock |
4.9% |
$195,821,018 |
-$18,962,586 |
2,084,311 |
-8.8% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| INSE |
INSPIRED ENTERTAINMENT, INC |
Common Stock |
4.9% |
$12,424,345 |
-$284,889 |
1,324,557 |
-2.2% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| FWONK |
LIBERTY MEDIA CORPORATION |
Series C Liberty Formula One Common Stock |
4.8% |
$1,121,643,010 |
-$292,351,894 |
10,738,564 |
-21% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| NEO |
NEOGENOMICS INC |
Common Stock |
4.8% |
$63,315,197 |
|
6,165,063 |
|
JANUS HENDERSON GROUP PLC |
31 Dec 2024 |
| EWTX |
EDGEWISE THERAPEUTICS, INC. |
Common Stock |
4.7% |
$80,764,749 |
-$8,499,572 |
4,979,331 |
-9.5% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| RNA |
AVIDITY BIOSCIENCES, INC. |
Common Stock |
4.6% |
$500,546,351 |
-$92,717,850 |
6,939,503 |
-16% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| WD |
WALKER & DUNLOP, INC. |
Common Stock |
4.6% |
$109,887,835 |
-$21,308,077 |
1,559,135 |
-16% |
JANUS HENDERSON GROUP PLC |
30 Jun 2025 |
| SKIN |
The Beauty Health Company |
Common Stock |
4.5% |
$10,922,459 |
-$4,854,238 |
5,718,565 |
-31% |
JANUS HENDERSON GROUP PLC |
30 Jun 2025 |
| BLKB |
BLACKBAUD, INC. |
Common Stock |
4.3% |
$135,336,329 |
-$48,644,075 |
2,122,257 |
-26% |
JANUS HENDERSON GROUP PLC |
31 Mar 2025 |
| AKRO |
AKERO THERAPEUTICS, INC. |
Common Stock |
4.1% |
$138,062,973 |
-$117,126,544 |
3,397,779 |
-46% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| TRDA |
ENTRADA THERAPEUTICS, INC. |
Common Stock |
4% |
$9,964,391 |
-$3,932,443 |
1,521,281 |
-28% |
JANUS HENDERSON GROUP PLC |
30 Jun 2025 |
| ETNB |
89bio, Inc. |
Common Stock |
3.6% |
$79,060,933 |
-$226,534,240 |
5,378,185 |
-74% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| ZLAB |
ZAI LAB LTD |
Common Stock |
3.6% |
|
|
39,501,040 |
-41% |
JANUS HENDERSON GROUP PLC |
31 Mar 2025 |
| CZR |
CAESARS ENTERTAINMENT INC |
Common Stock |
3.3% |
$198,781,761 |
|
7,101,885 |
|
JANUS HENDERSON GROUP PLC |
31 Dec 2024 |
| MTSR |
METSERA, INC. |
Common Stock |
3.1% |
$228,620,854 |
-$148,748,091 |
3,242,849 |
-39% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| DOX |
AMDOCS LIMITED |
Ordinary Shares |
2.3% |
$204,096,503 |
-$271,399,164 |
2,487,465 |
-57% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| IMNM |
IMMUNOME INC |
Common Stock |
2.2% |
$16,313,738 |
-$13,130,862 |
1,914,758 |
-45% |
JANUS HENDERSON GROUP PLC |
31 Mar 2025 |
| AVDL |
AVADEL PHARMACEUTICALS PLC |
Ordinary Shares |
1.9% |
$39,176,620 |
-$120,413,722 |
1,823,865 |
-75% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| PEPG |
PEPGEN INC |
Common Stock |
1.6% |
$835,610 |
|
522,256 |
|
JANUS HENDERSON GROUP PLC |
31 Dec 2024 |
| VRNA |
VERONA PHARMA PLC |
American Depositary Shares |
1.2% |
$107,837,284 |
-$546,765,073 |
1,010,564 |
-84% |
JANUS HENDERSON GROUP PLC |
30 Sep 2025 |
| OABI |
OMNIAB, INC. |
Common Stock |
0.8% |
$2,086,555 |
-$15,655,944 |
948,434 |
-88% |
JANUS HENDERSON GROUP PLC |
30 Jun 2025 |
| CATX |
PERSPECTIVE THERAPEUTICS INC |
Common Stock |
0% |
$43,349 |
|
17,839 |
|
JANUS HENDERSON GROUP PLC |
31 Dec 2024 |
| CRGX |
CARGO THERAPEUTICS, INC. |
Common Stock |
0% |
$36,577 |
-$13,068,842 |
7,900 |
-100% |
JANUS HENDERSON GROUP PLC |
31 Mar 2025 |
| APLT |
APPLIED THERAPEUTICS INC |
Common Stock |
0% |
$13,958 |
-$4,706,957 |
35,791 |
-100% |
JANUS HENDERSON GROUP PLC |
31 Dec 2024 |
| CTMX |
CytomX Therapeutics, Inc. |
Common Stock |
0% |
$0 |
|
0 |
|
JANUS HENDERSON GROUP PLC |
31 Dec 2024 |
| VTGN |
VISTAGEN THERAPEUTICS, INC. |
Common Stock |
0% |
$0 |
-$3,082,668 |
0 |
-100% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| LRMR |
LARIMAR THERAPEUTICS, INC. |
Common Stock |
0% |
$0 |
-$22,422,635 |
0 |
-100% |
JANUS HENDERSON GROUP PLC |
31 Mar 2025 |
| MREO |
MEREO BIOPHARMA GROUP PLC |
Ordinary Shares |
0% |
$0 |
-$10,751,486 |
0 |
-100% |
JANUS HENDERSON GROUP PLC |
31 Dec 2025 |
| NGNE |
NEUROGENE INC. |
Common Stock |
0% |
$0 |
|
0 |
|
JANUS HENDERSON GROUP PLC |
31 Dec 2024 |
| DTIL |
Precision BioSciences, Inc. |
Common Stock |
0% |
$0 |
|
0 |
|
JANUS HENDERSON GROUP PLC |
31 Dec 2024 |