Tyra Biosciences, Inc. - Common Stock, $0.0001 par value per share (the "Shares") (TYRA) Institutional Ownership

13F Institutional Holders and Ownership History from Q3 2021 to Q4 2025

Type / Class
Equity / Common Stock, $0.0001 par value per share (the "Shares")
Symbol
TYRA on Nasdaq
Shares outstanding
53,300,321
Price per share
$31.40
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
56,826,556
Total reported value
$1,493,885,313
% of total 13F portfolios
0.02%
Share change
+129,037
Value change
+$12,654,436
Number of holders
132
Price from insider filings
$31.40
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Tyra Biosciences, Inc. - Common Stock, $0.0001 par value per share (the "Shares") (TYRA) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
RA CAPITAL MANAGEMENT, L.P. 22% +12% $118,759,884 +$12,124,682 11,899,788 +11% RA Capital Management, L.P. 04 Jun 2025
Commodore Capital LP 6.3% +22% $47,216,250 +$8,743,750 3,375,000 +23% Commodore Capital LP 30 Sep 2025
Farallon Capital Partners, L.P. 5.6% $93,723,285 2,984,818 Dapice Joshua J. 12 Feb 2026
Canaan XI L.P. 5.5% -27% $88,938,975 -$24,301,882 2,930,444 -21% Canaan XI L.P. 31 Dec 2025
TCG Crossover GP I, LLC 5.7% $29,792,499 2,898,103 TCG Crossover GP I, LLC 27 Feb 2025
JANUS HENDERSON GROUP PLC 5.4% +6% $29,305,535 +$1,672,924 2,856,290 +6.1% JANUS HENDERSON GROUP PLC 30 Jun 2025
Harris Todd 5.1% $85,416,403 2,814,379 Todd Harris 31 Dec 2025
Vestal Point Capital, LP 4.5% -18% $33,925,750 -$6,363,058 2,425,000 -16% Vestal Point Capital, LP 30 Sep 2025
BIOTECHNOLOGY VALUE FUND L P 4% -48% $64,574,633 -$55,131,655 2,127,665 -46% BVF PARTNERS L P/IL 31 Dec 2025
FMR LLC 3.2% $17,549,481 1,707,148 FMR LLC 31 Mar 2025

As of 31 Dec 2025, 132 institutional investors reported holding 56,826,556 shares of Tyra Biosciences, Inc. - Common Stock, $0.0001 par value per share (the "Shares") (TYRA). This represents 107% of the company’s total 53,300,321 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of Tyra Biosciences, Inc. - Common Stock, $0.0001 par value per share (the "Shares") (TYRA) together control 99% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
RA CAPITAL MANAGEMENT, L.P. 23% 12,198,625 0% 3.3% $320,701,851
Nextech Invest, Ltd. 7.6% 4,055,861 0% 10% $106,628,586
Alta Partners Management Company, L.P. 7.2% 3,823,425 -6.3% 97% $100,517,843
Commodore Capital LP 6.3% 3,375,000 0% 5.9% $88,728,750
Canaan Partners XI LLC 6.3% 3,374,329 -6.5% 65% $88,711,109
JANUS HENDERSON GROUP PLC 5.5% 2,935,442 +2.1% 0.03% $77,084,707
TCG Crossover Management, LLC 5.4% 2,898,103 0% 2.5% $76,191,128
Vestal Point Capital, LP 4.5% 2,425,000 0% 2.3% $63,753,250
BVF INC/IL 4% 2,127,665 -42% 1.9% $55,936,313
BlackRock, Inc. 3.9% 2,086,423 +12% 0% $54,852,060
FARALLON CAPITAL MANAGEMENT LLC 3.9% 2,066,818 +81% 0.31% $54,336,645
VANGUARD GROUP INC 3% 1,572,785 +3.5% 0% $41,348,518
Kynam Capital Management, LP 2.9% 1,564,492 -33% 2.7% $41,130,495
5AM Venture Management, LLC 1.9% 1,029,298 +9.6% 8.5% $27,060,244
Caligan Partners LP 1.8% 944,257 +36% 2.3% $24,824,517
Point72 Asset Management, L.P. 1.6% 874,192 +210% 0.04% $22,982,508
Balyasny Asset Management L.P. 1.5% 818,326 -3.3% 0.04% $21,513,791
STATE STREET CORP 1.4% 749,463 +75% 0% $19,703,382
MARSHALL WACE, LLP 1.3% 711,891 +18% 0.02% $18,715,614
Trails Edge Capital Partners, LP 1.3% 700,000 0% 4.5% $18,403,000
GEODE CAPITAL MANAGEMENT, LLC 1.2% 657,756 +10% 0% $17,296,136
Sio Capital Management, LLC 0.99% 526,002 +2.1% 2.3% $13,828,593
BOONE CAPITAL MANAGEMENT LLC 0.75% 398,482 3.3% $10,476,092
Elmind Capital, LP 0.66% 350,000 0% 2.7% $9,201,500
Eversept Partners, LP 0.52% 278,564 +2.1% 0.41% $7,323,448

Institutional Holders of Tyra Biosciences, Inc. - Common Stock, $0.0001 par value per share (the "Shares") (TYRA) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 56,826,556 $1,493,885,313 +$12,654,436 $26.29 132
2025 Q3 55,638,635 $778,399,313 -$9,877,531 $13.99 115
2025 Q2 56,588,644 $541,513,140 +$28,813,504 $9.57 120
2025 Q1 53,573,458 $499,522,930 +$34,676,031 $9.30 116
2024 Q4 48,613,623 $675,760,666 -$145,254,713 $13.90 112
2024 Q3 47,054,295 $1,105,994,170 +$8,152,750 $23.51 94
2024 Q2 46,814,701 $748,570,507 -$1,810,347 $15.99 76
2024 Q1 46,852,011 $768,372,899 +$182,484,246 $16.40 75
2023 Q4 35,756,693 $495,188,385 -$9,797,725 $13.85 62
2023 Q3 36,462,633 $502,118,395 +$3,284,853 $13.77 59
2023 Q2 36,210,809 $616,671,033 +$8,028,494 $17.03 59
2023 Q1 35,654,296 $572,964,060 +$8,455,742 $16.07 50
2022 Q4 35,239,863 $267,821,738 -$5,207,345 $7.60 45
2022 Q3 35,692,923 $313,754,295 -$403,922 $8.79 43
2022 Q2 35,744,229 $255,572,000 -$3,322,156 $7.15 44
2022 Q1 36,133,976 $386,624,000 -$8,627,515 $10.70 46
2021 Q4 35,174,367 $494,157,000 +$13,654,547 $14.07 45
2021 Q3 26,080,552 $456,755,000 +$456,755,000 $17.59 25