PALISADE BIO, INC. - Common Stock, par value $0.01 per share (PALI) Institutional Ownership

13F Institutional Holders and Ownership History from Q2 2024 to Q4 2025

Type / Class
Equity / Common Stock, par value $0.01 per share
Symbol
PALI on Nasdaq
Shares outstanding
159,058,879
Price per share
$1.95
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
135,869,924
Total reported value
$319,349,625
% of total 13F portfolios
0%
Share change
+130,465,332
Value change
+$306,692,624
Number of holders
85
Price from insider filings
$1.95
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of PALISADE BIO, INC. - Common Stock, par value $0.01 per share (PALI) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
RA CAPITAL MANAGEMENT, L.P. 9.9% 0% $30,233,912 +$11,157,251 15,746,829 +58% RA Capital Management, L.P. 31 Dec 2025
PERCEPTIVE ADVISORS LLC 10% 0% $29,184,225 +$5,677,630 15,200,117 +24% Perceptive Advisors LLC 31 Dec 2025
JANUS HENDERSON GROUP PLC 10% $27,835,737 14,885,421 JANUS HENDERSON GROUP PLC 28 Nov 2025
Point72 Asset Management, L.P. 7% +13% $20,150,884 +$5,586,511 10,495,252 +38% Point72 Asset Management, L.P. 31 Dec 2025
Commodore Capital LP 9.9% $5,620,586 9,690,665 Commodore Capital LP 01 Oct 2025
Octagon Capital Advisors LP 6.4% $18,370,364 9,567,898 Octagon Capital Advisors LP 31 Dec 2025
FRANKLIN RESOURCES INC 6% $21,358,511 9,163,990 Franklin Resources, Inc. 31 Dec 2025
Squadron Capital Management LLC 3% -61% $8,640,000 -$7,200,000 4,500,000 -45% Squadron Master Fund LP 31 Dec 2025
ARMISTICE CAPITAL, LLC 10% 0% $335,053 +$132,407 471,906 +65% Armistice Capital, LLC 31 Mar 2025

As of 31 Dec 2025, 85 institutional investors reported holding 135,869,924 shares of PALISADE BIO, INC. - Common Stock, par value $0.01 per share (PALI). This represents 85% of the company’s total 159,058,879 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of PALISADE BIO, INC. - Common Stock, par value $0.01 per share (PALI) together control 78% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
PERCEPTIVE ADVISORS LLC 7.6% 12,050,000 0.52% $28,317,500
Commodore Capital LP 7.2% 11,445,000 1.8% $26,895,750
JANUS HENDERSON GROUP PLC 6.6% 10,540,334 0.01% $24,822,487
Point72 Asset Management, L.P. 6.6% 10,495,252 0.04% $24,663,842
Octagon Capital Advisors LP 6% 9,567,898 2.8% $22,484,560
RA CAPITAL MANAGEMENT, L.P. 4.5% 7,124,116 0.17% $16,741,673
AMERIPRISE FINANCIAL INC 4.3% 6,911,237 0% $16,241,408
Eversept Partners, LP 3.4% 5,391,548 0.71% $12,670,138
FRANKLIN RESOURCES INC 3.2% 5,092,562 0% $11,967,521
Boxer Capital Management, LLC 3% 4,799,875 2.5% $11,279,706
ADAGE CAPITAL PARTNERS GP, L.L.C. 2.8% 4,500,000 0.02% $10,575,000
Squadron Capital Management LLC 2.8% 4,500,000 0% 4.7% $10,575,000
B Group, Inc. 2.8% 4,500,000 7.8% $10,575,000
STEMPOINT CAPITAL LP 2.6% 4,192,375 1.7% $9,852,081
MORGAN STANLEY 2.6% 4,142,446 +47967% 0% $9,734,749
RENAISSANCE TECHNOLOGIES LLC 1.5% 2,382,500 0.01% $5,598,875
Vivo Capital, LLC 1.4% 2,293,578 0.35% $5,389,908
VANGUARD GROUP INC 1.3% 2,115,622 0% $4,971,711
ADAR1 Capital Management, LLC 1.3% 2,004,845 0.35% $4,711,386
Artia Global Partners LP 1.3% 1,992,367 0.75% $4,682,062
BlackRock, Inc. 1.2% 1,879,319 0% $4,416,400
ORBIMED ADVISORS LLC 1.2% 1,871,420 0.09% $4,397,837
CITADEL ADVISORS LLC 1.1% 1,701,411 0% $3,998,316
PRICE T ROWE ASSOCIATES INC /MD/ 0.99% 1,577,856 0% $3,708,000
GEODE CAPITAL MANAGEMENT, LLC 0.98% 1,565,452 +5781% 0% $3,680,760

Institutional Holders of PALISADE BIO, INC. - Common Stock, par value $0.01 per share (PALI) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 135,869,924 $319,349,625 +$306,692,624 $2.35 85
2025 Q3 119,592 $102,817 +$30,259 $0.86 12
2025 Q2 84,610 $57,544 -$119,036 $0.68 11
2025 Q1 260,593 $176,598 -$26,884 $0.68 11
2024 Q4 199,223 $328,718 +$210,668 $1.65 9
2024 Q3 62,098 $220,448 +$113,672 $3.55 8
2024 Q2 30,078 $135,352 +$135,352 $4.50 7