uniQure N.V. - Ordinary Shares, par value(euro)0.05 per share (QURE) Institutional Ownership

13F Institutional Holders and Ownership History from Q1 2014 to Q4 2025

Type / Class: Equity / Ordinary Shares, par value(euro)0.05 per share
Symbol: QURE on Nasdaq
Shares outstanding: 62,310,030
Price per share: $23.02
All holders as of 31 Dec 2025: Q4 2025
Total 13F shares: 61,704,943
Total reported value: $1,476,590,300
% of total 13F portfolios: 0.01%
Share change: +6,308,406
Value change: -$115,083,984
Number of holders: 220
Price from insider filings: $23.02

Reported Shares, Excluding Options vs Price

Reported Value, Excluding Options

Total Investors

Significant Owners of uniQure N.V. - Ordinary Shares, par value(euro)0.05 per share (QURE) based on Schedule 13D/G filings

Filer	Ownership	Change %	Holdings Value	Net Change	Nb Shares	Change %	Reporting Name	Report Period
Avoro Capital Advisors LLC	9.9%	+47%	$143,848,500	+$59,059,750	6,150,000	+70%	Avoro Capital Advisors LLC	31 Dec 2025
FMR LLC	9.8%		$353,697,322		6,059,574		FMR LLC	30 Sep 2025
RTW INVESTMENTS, LP	6%	-17%	$86,811,096	-$16,688,905	3,711,462	-16%	RTW Investments, LP	31 Dec 2025
Aberdeen Group plc	5.9%	+23%	$88,029,855	+$17,681,805	3,678,640	+25%	Aberdeen Group plc	31 Dec 2025
SUSQUEHANNA SECURITIES, LLC	5.7%		$82,718,384		3,536,485		G1 Execution Services, LLC	31 Dec 2025
STATE STREET CORP	5.2%		$75,574,096		3,231,043		STATE STREET CORPORATION	31 Dec 2025
Nantahala Capital Management, LLC	3.8%	-40%	$29,546,669	-$13,394,318	2,051,852	-31%	Nantahala Capital Management, LLC	30 Jun 2025
Vestal Point Capital, LP	0.4%	-91%	$13,133,250	-$202,835,750	225,000	-94%	Vestal Point Capital, LP	30 Sep 2025

As of 31 Dec 2025, 220 institutional investors reported holding 61,704,943 shares of uniQure N.V. - Ordinary Shares, par value(euro)0.05 per share (QURE). This represents 99% of the company’s total 62,310,030 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of uniQure N.V. - Ordinary Shares, par value(euro)0.05 per share (QURE) together control 73% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution	Ownership %	Shares Held	Share Change %	Portfolio %	Holdings Value
FMR LLC	10%	6,240,936	+3%	0.01%	$149,345,604
Avoro Capital Advisors LLC	9.9%	6,150,000	+38%	1.5%	$147,169,500
RTW INVESTMENTS, LP	6%	3,711,462	-16%	0.89%	$88,815,286
Aberdeen Group plc	5.9%	3,678,640	+25%	0.14%	$88,029,855
STATE STREET CORP	5.2%	3,231,043	+124%	0%	$77,318,859
JPMORGAN CHASE & CO	4.7%	2,934,626	+155%	0%	$70,225,603
BlackRock, Inc.	3.2%	1,974,988	+37%	0%	$47,261,464
TWO SIGMA INVESTMENTS, LP	2.3%	1,451,284	+62%	0.05%	$34,729,226
MPM BIOIMPACT LLC	2.2%	1,381,628		3.8%	$33,062,358
JENNISON ASSOCIATES LLC	2.2%	1,371,190	+37%	0.02%	$32,812,576
SUSQUEHANNA INTERNATIONAL GROUP, LLP	2%	1,218,350	+440%	0.04%	$29,155,116
SUVRETTA CAPITAL MANAGEMENT, LLC	2%	1,216,734		0.73%	$29,116,445
GOLDMAN SACHS GROUP INC	1.9%	1,167,608	+76%	0%	$27,940,859
TWO SIGMA ADVISERS, LP	1.8%	1,110,400	+171%	0.05%	$26,571,872
VANGUARD GROUP INC	1.7%	1,051,379	-6.6%	0%	$25,159,500
Artia Global Partners LP	1.6%	1,023,539	+55%	3.9%	$24,493,288
Integral Health Asset Management, LLC	1.4%	900,000	+50%	1.1%	$21,537,000
MILLENNIUM MANAGEMENT LLC	1.3%	803,605	+319%	0.01%	$19,230,268
GEODE CAPITAL MANAGEMENT, LLC	1.2%	776,071	+7.5%	0%	$18,578,179
Fiera Capital Corp	1.2%	768,510		0.06%	$18,390,444
FRANKLIN RESOURCES INC	1.2%	746,602	-62%	0%	$17,866,186
ORBIMED ADVISORS LLC	1.2%	737,400	+61%	0.38%	$17,645,982
MORGAN STANLEY	1.2%	716,927	+123%	0%	$17,156,063
Nantahala Capital Management, LLC	1.1%	699,298	-31%	1%	$16,734,201
Logos Global Management LP	1.1%	675,000	+125%	1.1%	$16,152,750

Institutional Holders of uniQure N.V. - Ordinary Shares, par value(euro)0.05 per share (QURE) across Reporting Periods

Period	Reported Shares, Excl. Options	Value, Excl. Options	Value Change	Puts Notional Value	Calls Notional Value	Price (Median)	Investors
2025 Q4	61,704,943	$1,476,590,300	-$115,083,984	$47,285,680	$163,965,917	$23.93	220
2025 Q3	55,352,343	$3,231,367,488	+$237,515,957	$231,706,629	$221,135,859	$58.37	218
2025 Q2	52,961,222	$738,302,097	+$50,637,556	$17,113,956	$58,468,510	$13.94	143
2025 Q1	49,986,625	$532,054,267	+$84,767,075	$4,602,520	$20,401,672	$10.60	139
2024 Q4	41,605,808	$734,372,507	+$59,578,946	$9,468,580	$41,283,182	$17.66	136
2024 Q3	38,874,270	$192,931,529	+$40,181,251	$2,815,030	$3,811,693	$4.93	129
2024 Q2	31,728,639	$141,844,153	-$3,825,259	$1,538,432	$5,874,624	$4.48	112
2024 Q1	32,322,300	$168,079,173	-$35,691,371	$2,898,480	$4,756,960	$5.20	130
2023 Q4	37,687,636	$255,220,282	-$8,276,086	$2,043,186	$6,225,692	$6.77	143
2023 Q3	35,800,237	$240,082,030	-$11,389,007	$2,137,806	$4,150,806	$6.71	160
2023 Q2	35,929,422	$411,603,802	-$102,920,571	$16,804,932	$26,646,544	$11.46	173
2023 Q1	41,579,108	$837,317,405	+$27,836,492	$13,256,148	$28,159,748	$20.14	170
2022 Q4	40,238,914	$912,094,750	-$33,364,677	$11,702,254	$50,851,077	$22.67	174
2022 Q3	42,072,015	$789,027,381	+$16,257,084	$5,869,456	$34,198,396	$18.76	155
2022 Q2	40,495,580	$754,734,025	+$52,181,297	$7,186,984	$40,886,944	$18.64	161
2022 Q1	37,951,511	$685,692,734	+$3,739,840	$8,479,782	$27,318,441	$18.07	162
2021 Q4	37,700,468	$782,152,012	-$10,555,469	$15,509,524	$104,678,720	$20.74	169
2021 Q3	37,029,922	$1,185,365,197	+$36,464,815	$17,264,000	$158,571,407	$32.01	170
2021 Q2	35,921,387	$1,106,406,897	-$14,666,760	$23,075,000	$147,300,000	$30.80	153
2021 Q1	36,324,502	$1,223,768,350	+$31,780,970	$15,378,000	$115,772,200	$33.69	153
2020 Q4	34,974,972	$1,263,910,909	-$11,650,805	$19,974,000	$72,650,738	$36.13	160
2020 Q3	35,272,720	$1,298,543,100	-$827,360	$22,082,000	$89,223,000	$36.83	157
2020 Q2	34,963,826	$1,573,348,794	-$20,279,224	$52,146,000	$93,186,000	$45.06	172
2020 Q1	35,310,616	$1,675,810,163	-$22,488,569	$40,427,000	$83,209,000	$47.45	167
2019 Q4	34,655,343	$2,483,224,906	+$183,794,307	$40,724,000	$119,006,000	$71.66	179
2019 Q3	32,038,308	$1,260,902,231	+$155,277,735	$19,944,000	$151,524,000	$39.36	155
2019 Q2	26,449,920	$2,066,161,619	+$440,721,480	$73,299,345	$324,346,000	$78.15	143
2019 Q1	22,704,127	$1,354,292,705	+$7,107,528	$14,435,000	$128,309,000	$59.65	128
2018 Q4	22,760,640	$655,512,079	-$4,279,771	$4,384,000	$44,297,000	$28.82	93
2018 Q3	22,572,035	$821,994,896	+$5,790,048	$4,000,000	$76,580,000	$36.39	98
2018 Q2	22,030,252	$832,692,000	+$220,229,387	$2,465,000	$79,202,000	$37.80	94
2018 Q1	16,267,232	$382,280,000	+$66,881,880	$1,168,000	$17,097,000	$23.50	66
2017 Q4	13,549,875	$265,453,073	+$106,494,269	$1,955,000	$11,065,000	$19.59	60
2017 Q3	7,666,082	$73,561,120	+$258,592			$9.60	35
2017 Q2	7,650,235	$47,354,000	+$3,032,085			$6.19	31
2017 Q1	7,213,970	$41,691,000	-$1,974,062	$1,000		$5.78	37
2016 Q4	7,619,508	$42,662,000	-$3,166,022	$2,000	$0	$5.60	50
2016 Q3	7,075,534	$54,129,000	-$8,015,435	$16,000	$142,000	$7.65	48
2016 Q2	8,137,564	$59,960,000	-$8,779,594	$202,000	$0	$7.37	57
2016 Q1	9,135,928	$108,531,000	+$7,848,398	$241,000	$126,000	$11.88	56
2015 Q4	8,219,077	$135,936,000	-$884,886	$1,830,000	$5,439,000	$16.54	64
2015 Q3	7,929,168	$162,145,000	-$249,360	$1,370,000	$7,128,000	$20.45	62
2015 Q2	7,678,180	$207,309,000	+$75,445,120	$578,000	$227,000	$27.00	53
2015 Q1	4,924,505	$119,703,000	+$32,132,767			$24.32	40
2014 Q4	3,821,918	$56,602,200	+$6,865,008			$14.81	27
2014 Q3	3,456,020	$31,869,000	-$65,722			$9.24	26
2014 Q2	3,422,576	$46,512,000	+$44,407			$13.59	26
2014 Q1	3,341,209	$51,981,000	+$51,981,000			$15.55	24