CRESCENT BIOPHARMA, INC. - Ordinary Shares, $0.001 par value per share (CBIO) Institutional Ownership

13F Institutional Holders and Ownership History from Q2 2025 to Q4 2025

Type / Class
Equity / Ordinary Shares, $0.001 par value per share
Symbol
CBIO on Nasdaq
Shares outstanding
28,063,832
Price per share
$13.63
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
23,741,798
Total reported value
$281,443,423
% of total 13F portfolios
0%
Share change
+12,046,496
Value change
+$142,716,069
Number of holders
54
Price from insider filings
$13.63
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of CRESCENT BIOPHARMA, INC. - Ordinary Shares, $0.001 par value per share (CBIO) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
Fairmount Funds Management LLC 19% -7.3% $73,252,396 +$32,700,021 5,643,482 +81% Fairmount Funds Management LLC 04 Dec 2025
FMR LLC 15% $49,932,849 4,133,514 FMR LLC 31 Dec 2025
Venrock Healthcare Capital Partners III, L.P. 9.5% $29,460,007 2,666,064 Venrock Healthcare Capital Partners III, L.P. 31 Dec 2025
ForGrowth III PA B.V. 6.1% $21,778,519 1,677,852 ForGrowth III PA B.V. 08 Dec 2025
Vestal Point Capital, LP 5.4% $16,575,000 1,500,000 Vestal Point Capital, LP 31 Dec 2025
BIOTECHNOLOGY VALUE FUND L P 10% $18,736,150 1,387,863 BVF PARTNERS L P/IL 30 Jun 2025
TANG CAPITAL MANAGEMENT LLC 5% $8,785,000 700,000 TANG CAPITAL MANAGEMENT, LLC 02 Oct 2025
Logos Global Management LP 4.1% $7,762,500 575,000 Logos Global Management LP 30 Jun 2025

As of 31 Dec 2025, 54 institutional investors reported holding 23,741,798 shares of CRESCENT BIOPHARMA, INC. - Ordinary Shares, $0.001 par value per share (CBIO). This represents 85% of the company’s total 28,063,832 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of CRESCENT BIOPHARMA, INC. - Ordinary Shares, $0.001 par value per share (CBIO) together control 81% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
FMR LLC 15% 4,133,514 +192% 0% $49,023,476
BVF INC/IL 9.8% 2,748,763 +98% 1.1% $32,600,329
Fairmount Funds Management LLC 9.8% 2,747,866 +98% 2.5% $32,589,691
VR ADVISER, LLC 7.6% 2,133,576 +54% 1.2% $25,304,211
FCPM III SERVICES B.V. 6% 1,677,852 2.6% $19,899,325
Vestal Point Capital, LP 5.3% 1,500,000 0.65% $17,790,000
Opaleye Management Inc. 4.2% 1,178,300 1.9% $13,974,638
TANG CAPITAL MANAGEMENT LLC 3.1% 872,398 +28% 0.51% $10,346,640
ADAR1 Capital Management, LLC 2.2% 606,000 0.54% $7,187,160
Logos Global Management LP 2.1% 600,000 0% 0.47% $7,116,000
VANGUARD GROUP INC 2% 557,506 -15% 0% $6,612,021
Deep Track Capital, LP 1.6% 453,686 0% 0.12% $5,380,716
Boxer Capital Management, LLC 1.6% 453,686 0% 1.2% $5,380,716
PERCEPTIVE ADVISORS LLC 1.6% 453,686 0% 0.1% $5,380,716
NEXTBio Capital Management LP 1.3% 372,856 0% 2.6% $4,422,072
RTW INVESTMENTS, LP 1.3% 372,856 0.04% $4,422,072
PRICE T ROWE ASSOCIATES INC /MD/ 1.2% 338,125 -12% 0% $4,011,000
Driehaus Capital Management LLC 1.1% 302,457 0% 0.02% $3,587,140
Point72 Asset Management, L.P. 1.1% 300,000 0.01% $3,558,000
Alyeska Investment Group, L.P. 0.94% 264,000 0.01% $3,108,992
HEIGHTS CAPITAL MANAGEMENT, INC 0.94% 264,000 1.2% $3,131,040
WELLINGTON MANAGEMENT GROUP LLP 0.51% 143,412 +710% 0% $1,626,774
TWO SIGMA INVESTMENTS, LP 0.45% 125,224 +342% 0% $1,485,157
Balyasny Asset Management L.P. 0.4% 111,715 0% $1,324,940
BlackRock, Inc. 0.39% 109,230 +0.11% 0% $1,295,468

Institutional Holders of CRESCENT BIOPHARMA, INC. - Ordinary Shares, $0.001 par value per share (CBIO) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 23,741,798 $281,443,423 +$142,716,069 $11.86 54
2025 Q3 11,318,865 $134,581,435 +$2,898,876 $11.89 40
2025 Q2 10,751,740 $173,532,467 +$173,532,402 $16.14 29