| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 9.8% | -21% | $177,773,201 | -$40,123,708 | 5,600,920 | -18% | FMR LLC | 31 Dec 2025 |
| RTW INVESTMENTS, LP | 10% | $50,498,414 | 5,310,033 | RTW Investments, LP | 31 Dec 2024 | |||
| Redmile Group, LLC | 8% | $52,554,931 | 4,375,931 | Redmile Group, LLC | 30 Jun 2025 | |||
| BlackRock, Inc. | 6.8% | +17% | $87,769,558 | +$14,428,761 | 3,732,540 | +20% | BlackRock, Inc. | 30 Sep 2025 |
| MORGAN STANLEY | 6.5% | $32,588,288 | 3,426,739 | Morgan Stanley | 31 Dec 2024 | |||
| BAKER BROS. ADVISORS LP | 5.8% | $105,906,763 | 3,336,697 | Baker Bros. Advisors LP | 31 Dec 2025 | |||
| TORONTO DOMINION BANK | 5.8% | $74,571,563 | 3,173,258 | The Toronto-Dominion Bank | 30 Sep 2025 | |||
| BlackRock Portfolio Management LLC | 4.7% | -8% | $28,946,115 | -$2,192,358 | 2,550,341 | -7% | BlackRock Portfolio Management LLC | 30 Jun 2025 |
| Skorpios Trust | 4.1% | -32% | $29,037,049 | -$12,870,000 | 2,256,181 | -31% | Montrago Trustees Ltd | 22 Aug 2025 |
As of 31 Dec 2025, 182 institutional investors reported holding 66,979,210 shares of Stoke Therapeutics, Inc. - Common Stock, par value $0.0001 per share (STOK). This represents 116% of the company’s total 57,529,259 outstanding shares.
The largest institutional shareholders of Stoke Therapeutics, Inc. - Common Stock, par value $0.0001 per share (STOK) together control 103% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 9.7% | 5,600,920 | -18% | 0.01% | $177,773,201 |
| RTW INVESTMENTS, LP | 9.6% | 5,546,856 | +8.3% | 1.8% | $176,057,209 |
| Lynx1 Capital Management LP | 9.4% | 5,404,674 | 0% | 35% | $171,544,353 |
| BlackRock, Inc. | 9.1% | 5,212,554 | -13% | 0% | $165,446,463 |
| Redmile Group, LLC | 7% | 4,034,070 | -3.4% | 9.4% | $128,041,382 |
| MORGAN STANLEY | 6.2% | 3,546,158 | +0.26% | 0.01% | $112,555,054 |
| BAKER BROS. ADVISORS LP | 5.8% | 3,336,697 | -28% | 0.62% | $105,906,763 |
| TORONTO DOMINION BANK | 5.5% | 3,173,258 | 0% | 0.18% | $100,719,209 |
| VANGUARD GROUP INC | 5.5% | 3,149,239 | -0.46% | 0% | $99,956,846 |
| STATE STREET CORP | 4.3% | 2,498,049 | +75% | 0% | $79,288,075 |
| BVF INC/IL | 3.9% | 2,265,674 | +37% | 2.4% | $71,912,493 |
| Siren, L.L.C. | 3.9% | 2,247,347 | 0% | 2.1% | $71,330,794 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3.2% | 1,823,500 | 0.74% | $57,877,890 | |
| JANUS HENDERSON GROUP PLC | 2.5% | 1,450,933 | +334% | 0.02% | $46,031,447 |
| Polar Capital Holdings Plc | 2.2% | 1,269,131 | -4.1% | 0.18% | $40,282,218 |
| Assenagon Asset Management S.A. | 2.1% | 1,227,723 | +36% | 0.06% | $38,967,928 |
| Point72 Asset Management, L.P. | 2.1% | 1,222,213 | -6.5% | 0.06% | $38,793,041 |
| GEODE CAPITAL MANAGEMENT, LLC | 2% | 1,166,145 | +1.7% | 0% | $37,019,868 |
| GOLDMAN SACHS GROUP INC | 2% | 1,142,737 | -0.71% | 0.01% | $36,270,472 |
| DIMENSIONAL FUND ADVISORS LP | 1.4% | 827,139 | +22% | 0.01% | $26,253,770 |
| MPM BIOIMPACT LLC | 1.3% | 770,289 | -2.5% | 2.8% | $24,448,973 |
| WELLINGTON MANAGEMENT GROUP LLP | 1.3% | 735,799 | -0.26% | 0% | $23,354,261 |
| Opaleye Management Inc. | 1.2% | 695,000 | +1.9% | 2.9% | $22,059,300 |
| TANG CAPITAL MANAGEMENT LLC | 0.87% | 500,000 | 0% | 0.78% | $15,870,000 |
| Candriam S.C.A. | 0.78% | 446,690 | 0.07% | $14,178,544 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 66,979,210 | $2,125,914,751 | +$58,218,861 | $31.74 | 182 |
| 2025 Q3 | 67,691,438 | $1,574,062,054 | +$64,325,425 | $23.50 | 151 |
| 2025 Q2 | 65,548,147 | $743,993,162 | +$30,166,679 | $11.35 | 133 |
| 2025 Q1 | 63,384,229 | $421,575,155 | +$30,343,505 | $6.65 | 124 |
| 2024 Q4 | 58,062,255 | $640,428,361 | -$5,638,079 | $11.03 | 129 |
| 2024 Q3 | 58,214,468 | $715,466,637 | -$45,762,031 | $12.29 | 116 |
| 2024 Q2 | 61,301,002 | $828,175,296 | +$96,412,204 | $13.51 | 114 |
| 2024 Q1 | 54,138,461 | $730,867,238 | +$123,726,512 | $13.50 | 101 |
| 2023 Q4 | 45,032,645 | $236,869,874 | +$6,784,370 | $5.26 | 81 |
| 2023 Q3 | 43,943,299 | $173,133,829 | -$18,481,683 | $3.94 | 96 |
| 2023 Q2 | 46,534,137 | $494,657,865 | +$21,008,744 | $10.63 | 98 |
| 2023 Q1 | 44,636,031 | $371,816,808 | +$35,289,257 | $8.33 | 97 |
| 2022 Q4 | 40,284,847 | $371,831,189 | -$22,554,117 | $9.23 | 106 |
| 2022 Q3 | 42,272,703 | $544,351,939 | -$11,748,534 | $12.84 | 99 |
| 2022 Q2 | 43,072,954 | $569,403,611 | +$19,595,358 | $13.21 | 88 |
| 2022 Q1 | 41,334,322 | $870,301,369 | +$123,934,287 | $21.05 | 96 |
| 2021 Q4 | 35,383,061 | $848,561,802 | +$26,332,046 | $23.99 | 91 |
| 2021 Q3 | 19,355,184 | $492,398,465 | -$30,803,526 | $25.44 | 89 |
| 2021 Q2 | 20,216,239 | $680,314,450 | -$703,085,149 | $33.66 | 96 |
| 2021 Q1 | 38,422,385 | $1,492,282,987 | -$15,747,693 | $38.84 | 104 |
| 2020 Q4 | 38,644,696 | $2,393,196,414 | +$252,468,837 | $61.93 | 93 |
| 2020 Q3 | 34,632,372 | $1,159,842,494 | +$2,937,942 | $33.49 | 89 |
| 2020 Q2 | 34,945,268 | $824,517,432 | +$9,797,711 | $23.83 | 70 |
| 2020 Q1 | 34,562,212 | $791,472,895 | +$23,374,012 | $22.90 | 67 |
| 2019 Q4 | 33,483,529 | $948,191,901 | +$22,388,802 | $28.32 | 64 |
| 2019 Q3 | 15,935,472 | $338,961,585 | +$30,078,348 | $21.49 | 52 |
| 2019 Q2 | 14,232,528 | $409,341,450 | +$409,341,450 | $29.17 | 47 |