| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Ikarian Capital, LLC | 11% | -46% | $1,060,227 | 121,356 | 0% | Ikarian Capital, LLC | 31 Oct 2025 | |
| INTEGRATED CORE STRATEGIES (US) LLC | 9.6% | $8,519,220 | 103,026 | Millennium Management LLC | 17 Feb 2026 | |||
| CITADEL ADVISORS LLC | 6.5% | -35% | $5,707,852 | -$3,228,541 | 70,035 | -36% | Kenneth Griffin | 31 Dec 2025 |
| Squadron Capital Management LLC | 6.5% | -1.4% | $5,705,000 | 70,000 | 0% | Squadron Master Fund LP | 31 Dec 2025 | |
| Boone Peter David Mr | 6.4% | $8,045,712 | 68,184 | Boone Peter David Mr | 21 Nov 2025 | |||
| Alyeska Investment Group, L.P. | 5.8% | $5,026,105 | 61,670 | Alyeska Investment Group, L.P. | 31 Dec 2025 | |||
| WELLINGTON MANAGEMENT GROUP LLP | 5.5% | $4,804,344 | 58,949 | Wellington Management Group LLP | 31 Dec 2025 | |||
| ADAR1 Capital Management, LLC | 5.4% | $4,796,020 | 58,000 | ADAR1 Capital Management, LLC | 31 Dec 2025 | |||
| Carlyle Group Inc. | 4.7% | $4,208,342 | 50,893 | The Carlyle Group Inc. | 18 Feb 2026 | |||
| HealthCap VIII, L.P. | 3.4% | $335,256 | 36,640 | HealthCap VIII, L.P. | 07 Oct 2025 |
As of 31 Dec 2025, 32 institutional investors reported holding 753,855 shares of SPRUCE BIOSCIENCES, INC. - Common Stock, par value $0.0001 per share (SPRB). This represents 70% of the company’s total 1,073,188 outstanding shares.
The largest institutional shareholders of SPRUCE BIOSCIENCES, INC. - Common Stock, par value $0.0001 per share (SPRB) together control 70% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Ikarian Capital, LLC | 11% | 121,356 | +810% | 1.4% | $10,571,320 |
| Squadron Capital Management LLC | 6.5% | 70,000 | 0% | 2.7% | $6,097,700 |
| CITADEL ADVISORS LLC | 6.5% | 69,999 | 0% | $6,097,613 | |
| WELLINGTON MANAGEMENT GROUP LLP | 5.5% | 58,949 | 0% | $5,135,048 | |
| ADAR1 Capital Management, LLC | 5.4% | 58,000 | 0.38% | $5,052,380 | |
| Alyeska Investment Group, L.P. | 4.8% | 51,671 | 0.01% | $4,501,061 | |
| BOOTHBAY FUND MANAGEMENT, LLC | 4.5% | 47,933 | 0.11% | $4,175,444 | |
| Balyasny Asset Management L.P. | 3.7% | 40,000 | 0.01% | $3,484,400 | |
| Carlyle Group Inc. | 3.6% | 38,620 | -99% | 0.02% | $3,298,920 |
| ExodusPoint Capital Management, LP | 2.4% | 25,271 | 0.02% | $2,201,357 | |
| Schonfeld Strategic Advisors LLC | 2.3% | 24,767 | 0.01% | $2,157,451 | |
| Quinn Opportunity Partners LLC | 2.1% | 22,810 | 0.09% | $1,986,979 | |
| Caligan Partners LP | 1.9% | 20,514 | 0.16% | $1,786,975 | |
| Stonepine Capital Management, LLC | 1.8% | 19,742 | 1.4% | $1,719,726 | |
| VANGUARD GROUP INC | 1.7% | 17,873 | 0% | $1,556,918 | |
| BlackRock, Inc. | 1.6% | 16,938 | 0% | $1,475,469 | |
| GEODE CAPITAL MANAGEMENT, LLC | 1.2% | 12,732 | 0% | $1,109,083 | |
| SUPERSTRING CAPITAL MANAGEMENT LP | 1.1% | 12,137 | 0.57% | $1,057,254 | |
| STATE STREET CORP | 0.6% | 6,400 | 0% | $557,504 | |
| UBS Group AG | 0.46% | 4,902 | +3614% | 0% | $427,013 |
| Resolute Capital Asset Partners LLC | 0.37% | 4,000 | 0.17% | $348,440 | |
| SkyView Investment Advisors, LLC | 0.28% | 3,000 | 0.03% | $261,000 | |
| NORTHERN TRUST CORP | 0.23% | 2,422 | 0% | $210,980 | |
| BNP PARIBAS FINANCIAL MARKETS | 0.19% | 2,000 | 0% | 0% | $174,220 |
| Lion Point Capital, LP | 0.09% | 1,000 | 0% | 0.45% | $87,110 |