Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN) Institutional Ownership

13F Institutional Holders and Ownership History from Q4 2024 to Q4 2025

Type / Class
Equity / Common Stock, $0.001 par value per share
Symbol
SEPN on Nasdaq
Shares outstanding
45,283,737
Price per share
$26.67
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
45,586,761
Total reported value
$1,270,841,828
% of total 13F portfolios
0%
Share change
+807,759
Value change
+$27,593,666
Number of holders
122
Price from insider filings
$26.67
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
Third Rock Ventures V, L.P. 14% 0% $43,509,137 6,215,591 0% Third Rock Ventures V, L.P. 31 Mar 2025
DRIEHAUS CAPITAL MANAGEMENT LLC 10% +49% $31,361,201 +$10,346,049 4,659,911 +49% DRIEHAUS CAPITAL MANAGEMENT LLC 31 May 2025
BIOTECHNOLOGY VALUE FUND L P 3.8% -61% $42,813,056 -$66,562,509 1,720,782 -61% BVF PARTNERS L P/IL 31 Dec 2025

As of 31 Dec 2025, 122 institutional investors reported holding 45,586,761 shares of Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN). This represents 101% of the company’s total 45,283,737 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN) together control 95% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
RA CAPITAL MANAGEMENT, L.P. 15% 6,995,858 0% 2% $195,044,521
TRV GP V, LLC 14% 6,215,591 0% 40% $173,290,677
Driehaus Capital Management LLC 11% 4,809,470 -2.2% 0.91% $134,088,024
TRV GP VI, LLC 9.3% 4,211,659 0% 79% $117,421,053
SAMSARA BIOCAPITAL, LLC 7% 3,149,128 0% 9.1% $87,797,689
GOLDMAN SACHS GROUP INC 6% 2,715,129 +87% 0.01% $75,697,796
Siren, L.L.C. 4.4% 2,000,000 -9.2% 1.7% $55,760,000
BlackRock, Inc. 4% 1,801,328 +23% 0% $50,221,023
BVF INC/IL 3.8% 1,720,782 -57% 1.6% $47,975,402
VANGUARD GROUP INC 3.3% 1,508,195 -0.7% 0% $42,048,476
Avoro Capital Advisors LLC 3% 1,337,500 0% 0.37% $37,289,500
ADAR1 Capital Management, LLC 2.6% 1,157,611 -1.6% 2.4% $32,274,195
First Light Asset Management, LLC 1.4% 620,811 1.3% $17,308,211
VR ADVISER, LLC 1.3% 610,808 0% 0.84% $17,029,327
GEODE CAPITAL MANAGEMENT, LLC 1.3% 572,734 +5% 0% $15,971,458
Casdin Capital, LLC 1.2% 553,268 0% 0.96% $15,425,112
PRIMECAP MANAGEMENT CO/CA/ 1.2% 546,100 0.01% $15,225,268
STATE STREET CORP 1.2% 540,028 +29% 0% $15,055,981
PERCEPTIVE ADVISORS LLC 0.96% 433,160 -20% 0.22% $12,076,501
Woodline Partners LP 0.85% 385,310 +36% 0.04% $10,742,443
Soleus Capital Management, L.P. 0.85% 383,368 +1999% 0.45% $10,688,300
Catalio Capital Management, LP 0.65% 294,360 0% 1.5% $8,206,757
MARSHALL WACE, LLP 0.5% 226,901 0.01% $6,326,001
Universal- Beteiligungs- und Servicegesellschaft mbH 0.49% 222,702 0% 0.01% $6,208,932
Kalehua Capital Management LLC 0.43% 194,544 0% 5.5% $5,423,887

Institutional Holders of Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 45,586,761 $1,270,841,828 +$27,593,666 $27.88 122
2025 Q3 44,549,033 $837,968,810 +$6,406,562 $18.81 82
2025 Q2 44,430,464 $469,630,218 -$8,199,247 $10.57 89
2025 Q1 45,290,316 $262,246,506 -$67,734,233 $5.79 69
2024 Q4 44,129,388 $1,010,571,873 +$770,183,886 $22.90 71