Oruka Therapeutics, Inc. - Common Stock, $0.001 par value (ORKA) Institutional Ownership

13F Institutional Holders and Ownership History from Q3 2024 to Q4 2025

Type / Class
Equity / Common Stock, $0.001 par value
Symbol
ORKA on Nasdaq
Shares outstanding
47,863,907
Price per share
$34.12
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
52,849,512
Total reported value
$1,601,909,476
% of total 13F portfolios
0%
Share change
+5,584,899
Value change
+$170,659,397
Number of holders
141
Price from insider filings
$34.12
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Oruka Therapeutics, Inc. - Common Stock, $0.001 par value (ORKA) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
Fairmount Funds Management LLC 20% 0% $161,971,372 +$38,464,806 11,162,741 +31% Fairmount Funds Management LLC 17 Sep 2025
Venrock Healthcare Capital Partners III, L.P. 9.9% -11% $94,411,973 +$14,637,703 4,909,619 +18% Venrock Healthcare Capital Partners III, L.P. 30 Sep 2025
BlackRock, Inc. 6.6% +42% $96,248,890 +$29,642,149 3,175,483 +45% BlackRock, Inc. 31 Dec 2025
VIKING GLOBAL INVESTORS LP 5.5% $38,693,672 2,666,690 VIKING GLOBAL INVESTORS LP 17 Sep 2025
VANGUARD GROUP INC 5.1% $74,366,494 2,453,530 The Vanguard Group 31 Dec 2025
Deep Track Capital, LP 4.5% -12% $65,515,368 +$8,023,966 2,161,510 +14% Deep Track Capital, LP 31 Dec 2025
RTW INVESTMENTS, LP 4.3% -18% $62,382,466 +$3,409,845 2,058,148 +5.8% RTW Investments, LP 31 Dec 2025

As of 31 Dec 2025, 141 institutional investors reported holding 52,849,512 shares of Oruka Therapeutics, Inc. - Common Stock, $0.001 par value (ORKA). This represents 110% of the company’s total 47,863,907 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of Oruka Therapeutics, Inc. - Common Stock, $0.001 par value (ORKA) together control 96% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
FMR LLC 15% 7,261,384 +0.05% 0.01% $220,092,549
VR ADVISER, LLC 8.7% 4,148,428 0% 6.2% $125,738,853
Fairmount Funds Management LLC 7.7% 3,705,262 0% 8.5% $112,306,491
BlackRock, Inc. 7.4% 3,539,415 +61% 0% $107,279,669
VIKING GLOBAL INVESTORS LP 5.6% 2,666,690 0% 0.21% $80,827,374
VANGUARD GROUP INC 5.1% 2,453,530 +38% 0% $74,366,494
Deep Track Capital, LP 4.5% 2,161,510 -19% 1.5% $65,515,368
RTW INVESTMENTS, LP 4.3% 2,058,148 +5.8% 0.62% $62,382,466
Commodore Capital LP 3.7% 1,753,054 0% 3.5% $53,135,067
Paradigm Biocapital Advisors LP 3.6% 1,710,316 1.4% $51,839,678
Remedium Capital Partners, LLC 3.2% 1,552,414 0% 28% $47,054,000
PERCEPTIVE ADVISORS LLC 3.1% 1,476,501 +16% 0.82% $44,752,745
STATE STREET CORP 2.9% 1,383,847 +112% 0% $41,944,403
Avoro Capital Advisors LLC 2.8% 1,333,340 0% 0.4% $40,413,535
Blackstone Inc. 2.4% 1,165,408 +37% 0.15% $35,323,516
Polar Capital Holdings Plc 2% 978,288 -5.2% 0.14% $29,651,909
GEODE CAPITAL MANAGEMENT, LLC 2% 942,507 +37% 0% $28,574,387
FRANKLIN RESOURCES INC 2% 938,421 -12% 0.01% $28,443,541
Affinity Asset Advisors, LLC 1.7% 802,342 -16% 1.7% $24,318,986
MERCER GLOBAL ADVISORS INC /ADV 1.6% 745,277 -13% 0.03% $22,589,346
CITADEL ADVISORS LLC 1.5% 726,118 +129% 0.01% $22,008,637
Avidity Partners Management LP 1.4% 660,424 0% 5.8% $20,017,451
PRICE T ROWE ASSOCIATES INC /MD/ 1.4% 649,346 +3.6% 0% $19,683,000
Point72 Asset Management, L.P. 1.3% 600,000 -42% 0.03% $18,186,000
Woodline Partners LP 1.2% 574,553 +0.04% 0.07% $17,414,701

Institutional Holders of Oruka Therapeutics, Inc. - Common Stock, $0.001 par value (ORKA) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 52,849,512 $1,601,909,476 +$170,659,397 $30.31 141
2025 Q3 45,557,412 $875,823,009 +$220,884,566 $19.23 104
2025 Q2 34,429,035 $385,950,468 +$30,431,109 $11.21 81
2025 Q1 31,776,517 $326,087,518 -$21,453,560 $10.26 70
2024 Q4 31,038,311 $606,624,310 +$125,781,752 $19.39 66
2024 Q3 24,559,501 $604,174,991 +$603,646,384 $24.51 41