OnKure Therapeutics, Inc. - Class A Common Stock, par value $0.0001 per share (OKUR) Institutional Ownership

13F Institutional Holders and Ownership History from Q3 2024 to Q4 2025

Type / Class
Equity / Class A Common Stock, par value $0.0001 per share
Symbol
OKUR on Nasdaq
Shares outstanding
12,837,443
Price per share
$3.14
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
11,035,466
Total reported value
$31,918,032
% of total 13F portfolios
0%
Share change
+618,440
Value change
+$1,811,754
Number of holders
41
Price from insider filings
$3.14
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of OnKure Therapeutics, Inc. - Class A Common Stock, par value $0.0001 per share (OKUR) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
ACORN BIOVENTURES, L.P. 22% $7,099,185 2,839,674 Anders Hove 15 May 2025
ADAR1 Capital Management, LLC 7.9% $3,184,456 1,014,158 ADAR1 Capital Management, LLC 31 Dec 2025
Shay Capital LLC 6.3% $2,057,944 810,214 Shay Capital LLC 15 May 2025
Prosight Management, LP 5.8% $2,214,578 745,649 Prosight Management, LP 24 Nov 2025
CANTOR FITZGERALD & CO. 5.2% $1,606,894 669,539 Cantor Fitzgerald Securities 30 Jun 2025
VANGUARD GROUP INC 4.9% -12% $1,815,303 -$232,174 626,593 -11% The Vanguard Group 31 Dec 2025
HIGHBRIDGE CAPITAL MANAGEMENT LLC 4.2% -20% $1,703,014 -$380,712 542,361 -18% Highbridge Capital Management, LLC 31 Dec 2025
Deep Track Capital, LP 4.1% $1,330,932 523,989 Deep Track Capital, LP 31 Dec 2024
CITADEL ADVISORS LLC 1.7% $700,612 223,125 Kenneth Griffin 31 Dec 2025
Lundbeckfond Invest A/S 1.6% $515,930 203,122 Lundbeckfond Invest A/S 31 Dec 2024

As of 31 Dec 2025, 41 institutional investors reported holding 11,035,466 shares of OnKure Therapeutics, Inc. - Class A Common Stock, par value $0.0001 per share (OKUR). This represents 86% of the company’s total 12,837,443 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of OnKure Therapeutics, Inc. - Class A Common Stock, par value $0.0001 per share (OKUR) together control 85% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
ACORN CAPITAL ADVISORS, LLC 22% 2,839,674 0% 2.8% $8,235,055
ADAR1 Capital Management, LLC 7.9% 1,014,158 0.22% $2,941,058
Prosight Management, LP 6.4% 816,909 +205% 0.49% $2,369,036
Shay Capital LLC 6.1% 780,861 -15% 0.37% $2,264,497
Rosalind Advisors, Inc. 5.7% 730,488 0.81% $2,118,415
Vestal Point Capital, LP 4.9% 635,000 0% 0.07% $1,841,500
VANGUARD GROUP INC 4.9% 626,593 -7.6% 0% $1,817,120
HIGHBRIDGE CAPITAL MANAGEMENT LLC 4.2% 542,361 -17% 0.07% $1,572,847
StepStone Group LP 3.8% 491,938 0% 0.78% $1,352,830
NEA Management Company, LLC 3.7% 478,548 0% 0.07% $1,387,789
CANTOR FITZGERALD, L. P. 3.5% 445,078 -9.5% 0.04% $1,290,726
Carlyle Group Inc. 2.1% 269,895 0% 0.01% $771,900
RENAISSANCE TECHNOLOGIES LLC 1.9% 247,350 +41% 0% $717,315
CITADEL ADVISORS LLC 1.7% 223,125 -78% 0% $647,062
KOTLER KEVIN 1.5% 197,691 0% 0.42% $573,304
Rangeley Capital, LLC 1.1% 145,000 -6.7% 0.37% $420,500
Aisling Capital Management LP 0.69% 88,607 0% 0.05% $256,960
GEODE CAPITAL MANAGEMENT, LLC 0.6% 77,469 -8.7% 0% $224,674
SPHERA FUNDS MANAGEMENT LTD. 0.47% 60,454 0% 0.04% $175,317
BlackRock, Inc. 0.41% 52,678 -91% 0% $152,766
GSA CAPITAL PARTNERS LLP 0.36% 45,948 -22% 0.01% $133,000
Aldebaran Capital, LLC 0.32% 41,284 -6.2% 0.11% $119,724
BARCLAYS PLC 0.21% 27,242 +4287% 0% $79,002
TWO SIGMA ADVISERS, LP 0.21% 26,608 0% 0% $77,163
MORGAN STANLEY 0.19% 24,962 +45% 0% $72,390

Institutional Holders of OnKure Therapeutics, Inc. - Class A Common Stock, par value $0.0001 per share (OKUR) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 11,035,466 $31,918,032 +$1,811,754 $2.90 41
2025 Q3 10,219,418 $28,103,553 -$1,295,979 $2.75 41
2025 Q2 10,778,865 $25,758,405 -$10,457,913 $2.39 48
2025 Q1 11,945,383 $50,147,392 -$1,567,896 $4.30 46
2024 Q4 11,839,453 $99,220,652 +$88,963,332 $8.60 50
2024 Q3 3,200 $5,440 +$5,440 $1.70 1