| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| JPMORGAN CHASE & CO | 11% | +36% | $2,827,801,936 | +$964,491,533 | 23,014,584 | +52% | JPMORGAN CHASE & CO. | 29 Aug 2025 |
| Darwin Global Management, Ltd. | 9.7% | +13% | $2,946,076,654 | +$728,614,275 | 20,457,445 | +33% | Darwin Global Management, Ltd. | 30 Sep 2025 |
| VANGUARD GROUP INC | 10% | $1,256,380,378 | 18,218,973 | The Vanguard Group | 31 Dec 2024 | |||
| BlackRock, Inc. | 6.6% | +30% | $2,457,696,288 | +$764,349,568 | 14,121,445 | +45% | BlackRock, Inc. | 31 Dec 2025 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3.3% | -43% | $998,278,616 | -$619,088,189 | 6,932,009 | -38% | T. Rowe Price Associates, Inc. | 30 Sep 2025 |
As of 31 Dec 2025, 663 institutional investors reported holding 212,244,595 shares of INSMED Inc - Common Stock (INSM). This represents 99% of the company’s total 213,961,288 outstanding shares.
The largest institutional shareholders of INSMED Inc - Common Stock (INSM) together control 72% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| JPMORGAN CHASE & CO | 11% | 23,199,512 | +0.66% | 0.27% | $4,037,643,311 |
| VANGUARD GROUP INC | 9.9% | 21,076,344 | +5.7% | 0.05% | $3,668,126,910 |
| Darwin Global Management, Ltd. | 9.8% | 20,933,277 | +2.3% | 74% | $3,644,274,193 |
| BlackRock, Inc. | 7% | 15,065,052 | +22% | 0.04% | $2,621,921,693 |
| FMR LLC | 4.6% | 9,927,936 | +8.1% | 0.09% | $1,727,857,942 |
| BAKER BROS. ADVISORS LP | 3.1% | 6,592,746 | -1.7% | 6.7% | $1,147,401,514 |
| STATE STREET CORP | 2.4% | 5,201,744 | +31% | 0.03% | $905,311,526 |
| Capital International Investors | 2.4% | 5,151,671 | -32% | 0.14% | $896,597,082 |
| Artisan Partners Limited Partnership | 2.3% | 4,843,749 | -1.9% | 1.3% | $843,006,016 |
| RTW INVESTMENTS, LP | 2.3% | 4,842,879 | +57% | 8.4% | $842,854,661 |
| D. E. Shaw & Co., Inc. | 2% | 4,350,995 | -23% | 0.58% | $757,247,170 |
| GEODE CAPITAL MANAGEMENT, LLC | 2% | 4,299,052 | +14% | 0.05% | $751,935,864 |
| Orbis Allan Gray Ltd | 2% | 4,179,957 | +29% | 3% | $727,479,716 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.9% | 4,039,466 | -42% | 0.08% | $703,030,000 |
| NORGES BANK | 1.4% | 2,910,971 | 0.05% | $506,625,393 | |
| FRANKLIN RESOURCES INC | 1.3% | 2,755,536 | +29% | 0.12% | $479,573,482 |
| Invesco Ltd. | 1.3% | 2,726,857 | +36% | 0.07% | $474,582,256 |
| AMERIPRISE FINANCIAL INC | 0.92% | 1,968,857 | -28% | 0.08% | $342,660,797 |
| UBS Group AG | 0.87% | 1,867,635 | +13% | 0.06% | $325,043,194 |
| BANK OF AMERICA CORP /DE/ | 0.81% | 1,725,681 | +7.7% | 0.02% | $300,337,528 |
| MORGAN STANLEY | 0.76% | 1,631,905 | +69% | 0.02% | $284,017,140 |
| Duquesne Family Office LLC | 0.69% | 1,481,752 | -39% | 6.1% | $257,884,000 |
| Bank of New York Mellon Corp | 0.65% | 1,390,042 | +22% | 0.04% | $241,922,940 |
| MILLENNIUM MANAGEMENT LLC | 0.61% | 1,311,654 | -44% | 0.16% | $228,280,262 |
| Castle Hook Partners LP | 0.59% | 1,253,568 | +15% | 3.1% | $218,170,975 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 212,244,595 | $36,947,382,246 | +$163,945,428 | $174.04 | 663 |
| 2025 Q3 | 210,869,370 | $30,324,270,480 | +$447,352,869 | $144.01 | 563 |
| 2025 Q2 | 210,375,071 | $21,148,644,502 | +$1,358,877,009 | $100.64 | 513 |
| 2025 Q1 | 197,789,205 | $15,117,195,698 | +$439,219,800 | $76.29 | 436 |
| 2024 Q4 | 192,544,545 | $13,293,875,240 | +$244,780,319 | $69.04 | 434 |
| 2024 Q3 | 188,054,494 | $13,732,893,406 | +$900,536,797 | $73.00 | 411 |
| 2024 Q2 | 175,240,601 | $11,740,766,805 | +$1,771,359,793 | $67.00 | 375 |
| 2024 Q1 | 149,761,616 | $4,062,731,615 | -$1,104,814 | $27.13 | 284 |
| 2023 Q4 | 149,731,871 | $4,640,473,667 | +$24,712,854 | $30.99 | 269 |
| 2023 Q3 | 147,357,091 | $3,720,846,962 | +$68,976,618 | $25.25 | 249 |
| 2023 Q2 | 146,401,839 | $3,087,320,690 | +$30,211,671 | $21.10 | 221 |
| 2023 Q1 | 145,487,988 | $2,479,157,946 | +$29,238,110 | $17.05 | 229 |
| 2022 Q4 | 143,724,717 | $2,870,747,315 | +$305,150,296 | $19.98 | 224 |
| 2022 Q3 | 127,521,278 | $2,746,157,362 | -$212,666,313 | $21.54 | 229 |
| 2022 Q2 | 129,190,615 | $2,547,619,834 | +$40,332,207 | $19.72 | 200 |
| 2022 Q1 | 126,479,239 | $2,971,923,265 | +$75,140,734 | $23.50 | 211 |
| 2021 Q4 | 123,318,469 | $3,358,792,092 | -$21,477,249 | $27.24 | 201 |
| 2021 Q3 | 123,374,100 | $3,397,087,163 | +$40,469,427 | $27.54 | 184 |
| 2021 Q2 | 121,478,330 | $3,456,376,124 | +$431,176,988 | $28.46 | 194 |
| 2021 Q1 | 106,602,088 | $3,631,335,192 | -$6,653,428 | $34.06 | 194 |
| 2020 Q4 | 107,580,874 | $3,581,395,788 | -$44,371,673 | $33.29 | 202 |
| 2020 Q3 | 108,714,504 | $3,495,053,137 | -$56,966,505 | $32.14 | 195 |
| 2020 Q2 | 110,715,810 | $3,045,474,894 | +$374,929,259 | $27.54 | 183 |
| 2020 Q1 | 97,643,990 | $1,563,236,817 | -$41,156,048 | $16.03 | 159 |
| 2019 Q4 | 98,329,079 | $2,348,053,229 | -$38,855,319 | $23.88 | 169 |
| 2019 Q3 | 99,035,921 | $1,747,100,746 | -$518,153,737 | $17.64 | 153 |
| 2019 Q2 | 126,395,360 | $3,235,565,096 | +$1,146,114,720 | $25.60 | 165 |
| 2019 Q1 | 82,194,605 | $2,389,348,616 | -$1,132,072 | $29.07 | 151 |
| 2018 Q4 | 82,419,564 | $1,081,320,258 | -$9,481,669 | $13.12 | 120 |
| 2018 Q3 | 80,880,640 | $1,635,485,434 | -$43,612,626 | $20.22 | 120 |
| 2018 Q2 | 82,447,822 | $1,949,876,562 | +$16,668,558 | $23.65 | 125 |
| 2018 Q1 | 81,818,840 | $1,842,516,409 | +$127,505,884 | $22.52 | 125 |
| 2017 Q4 | 75,871,275 | $2,365,660,554 | +$39,137,828 | $31.18 | 125 |
| 2017 Q3 | 73,705,883 | $2,300,049,892 | +$548,691,894 | $31.21 | 142 |
| 2017 Q2 | 56,526,187 | $969,760,710 | +$39,905,047 | $17.16 | 110 |
| 2017 Q1 | 56,998,661 | $998,026,125 | +$70,030,475 | $17.51 | 97 |
| 2016 Q4 | 57,799,199 | $764,693,750 | +$2,353,629 | $13.23 | 96 |
| 2016 Q3 | 57,474,912 | $834,201,194 | +$19,054,121 | $14.52 | 93 |
| 2016 Q2 | 56,451,131 | $556,714,141 | -$8,091,952 | $9.86 | 103 |
| 2016 Q1 | 57,022,278 | $722,305,325 | -$13,027,221 | $12.67 | 97 |
| 2015 Q4 | 56,887,745 | $1,032,792,029 | -$19,917 | $18.15 | 111 |
| 2015 Q3 | 56,767,734 | $1,053,879,972 | +$35,530,012 | $18.57 | 117 |
| 2015 Q2 | 54,410,404 | $1,328,450,938 | +$21,929,946 | $24.42 | 115 |
| 2015 Q1 | 53,709,876 | $1,117,417,187 | +$261,082,690 | $20.80 | 117 |
| 2014 Q4 | 41,928,477 | $648,686,215 | +$11,193,962 | $15.47 | 94 |
| 2014 Q3 | 41,271,273 | $538,679,902 | +$115,361,476 | $13.05 | 99 |
| 2014 Q2 | 31,011,972 | $619,318,286 | +$3,350,731 | $19.98 | 102 |
| 2014 Q1 | 30,157,438 | $573,214,840 | +$41,465,686 | $19.04 | 108 |