Fulcrum Therapeutics, Inc. - Common Stock, $0.001 par value per share (FULC) Institutional Ownership

13F Institutional Holders and Ownership History from Q3 2019 to Q4 2025

Type / Class
Equity / Common Stock, $0.001 par value per share
Symbol
FULC on Nasdaq
Shares outstanding
67,171,444
Price per share
$10.94
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
67,401,963
Total reported value
$762,255,313
% of total 13F portfolios
0%
Share change
+11,833,245
Value change
+$135,115,239
Number of holders
170
Price from insider filings
$10.94
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Fulcrum Therapeutics, Inc. - Common Stock, $0.001 par value per share (FULC) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
RA CAPITAL MANAGEMENT, L.P. 9.9% -12% $67,231,227 +$6,025,691 6,649,973 +9.8% RA Capital Management, L.P. 31 Dec 2025
SUVRETTA CAPITAL MANAGEMENT, LLC 9.4% +52% $18,495,988 +$6,069,154 5,067,394 +49% SUVRETTA CAPITAL MANAGEMENT, LLC 31 Mar 2025
Nantahala Capital Management, LLC 7.7% $17,439,379 4,777,912 Nantahala Capital Management, LLC 30 Sep 2024
BlackRock, Inc. 6% -19% $30,090,560 -$7,016,336 3,270,322 -19% BlackRock, Inc. 30 Sep 2025
Adage Capital Management, L.P. 4.5% -44% $22,374,400 -$19,844,400 2,432,000 -47% Adage Capital Management, L.P. 30 Sep 2025

As of 31 Dec 2025, 170 institutional investors reported holding 67,401,963 shares of Fulcrum Therapeutics, Inc. - Common Stock, $0.001 par value per share (FULC). This represents 100% of the company’s total 67,171,444 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of Fulcrum Therapeutics, Inc. - Common Stock, $0.001 par value per share (FULC) together control 85% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
SUVRETTA CAPITAL MANAGEMENT, LLC 9.8% 6,561,111 +22% 1.8% $74,206,165
RA CAPITAL MANAGEMENT, L.P. 9% 6,053,960 -41% 0.7% $68,470,288
TCG Crossover Management, LLC 7.8% 5,250,000 0% 2% $59,377,500
Nantahala Capital Management, LLC 6.4% 4,293,346 -8.1% 2.9% $48,557,743
BlackRock, Inc. 6.3% 4,263,761 +15% 0% $48,223,137
VANGUARD GROUP INC 5.3% 3,559,552 +19% 0% $40,258,533
BRAIDWELL LP 4.6% 3,061,222 +1295% 1.1% $34,622,421
Point72 Asset Management, L.P. 3.6% 2,398,232 0.04% $27,124,004
Siren, L.L.C. 2.9% 1,950,000 0.66% $22,054,500
D. E. Shaw & Co., Inc. 2.8% 1,913,755 +32% 0.02% $21,644,569
First Turn Management, LLC 2.8% 1,892,683 2.4% $21,406,245
GSK plc 2.7% 1,785,714 0% 2.5% $20,196,425
ADAGE CAPITAL PARTNERS GP, L.L.C. 2.5% 1,700,000 -30% 0.03% $19,227,000
Ikarian Capital, LLC 2% 1,375,472 +6.7% 2% $15,556,588
Aberdeen Group plc 1.9% 1,254,027 +809% 0.02% $14,183,045
ADAR1 Capital Management, LLC 1.9% 1,253,749 +267% 1.1% $14,179,901
CITADEL ADVISORS LLC 1.8% 1,207,004 +41% 0.01% $13,651,216
GEODE CAPITAL MANAGEMENT, LLC 1.6% 1,105,813 +10% 0% $12,509,702
DIMENSIONAL FUND ADVISORS LP 1.6% 1,051,124 -19% 0% $11,888,372
STATE STREET CORP 1.5% 1,005,345 -5.4% 0% $11,370,452
Balyasny Asset Management L.P. 1.4% 970,439 -33% 0.02% $10,975,665
Vestal Point Capital, LP 1.4% 950,000 0.39% $10,744,500
GREAT POINT PARTNERS LLC 1.2% 800,000 2.9% $9,048,000
ACADIAN ASSET MANAGEMENT LLC 1.1% 736,740 +36% 0.01% $8,326,000
Connor, Clark & Lunn Investment Management Ltd. 0.87% 582,377 +52% 0.02% $6,586,684

Institutional Holders of Fulcrum Therapeutics, Inc. - Common Stock, $0.001 par value per share (FULC) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 67,401,963 $762,255,313 +$135,115,239 $11.31 170
2025 Q3 53,790,538 $494,909,349 -$1,273,053 $9.20 127
2025 Q2 54,400,644 $374,498,177 +$23,533,452 $6.88 122
2025 Q1 51,307,184 $147,764,693 -$3,070,431 $2.88 115
2024 Q4 51,666,381 $242,831,448 -$8,308,464 $4.70 117
2024 Q3 54,857,560 $195,845,950 -$86,380,213 $3.57 127
2024 Q2 64,752,304 $401,470,762 +$19,716,085 $6.20 120
2024 Q1 60,342,845 $569,639,654 -$2,974,963 $9.44 122
2023 Q4 61,083,723 $412,326,970 +$14,153,071 $6.75 100
2023 Q3 56,394,454 $250,394,156 +$9,019,379 $4.44 79
2023 Q2 55,518,138 $183,197,485 -$14,257,183 $3.30 85
2023 Q1 60,413,854 $172,155,022 +$51,602 $2.85 115
2022 Q4 50,644,890 $368,693,025 -$13,010,376 $7.28 109
2022 Q3 52,209,184 $422,360,458 +$98,764,326 $8.09 104
2022 Q2 40,127,745 $196,621,873 -$32,729,118 $4.90 97
2022 Q1 39,071,704 $923,864,555 +$64,674,079 $23.65 104
2021 Q4 37,197,291 $657,236,909 -$42,835,792 $17.69 107
2021 Q3 36,552,286 $1,031,536,477 +$305,128,643 $28.21 100
2021 Q2 26,798,436 $280,833,000 -$3,275,840 $10.48 66
2021 Q1 26,913,060 $317,031,000 +$45,552,581 $11.78 68
2020 Q4 22,170,825 $259,615,000 +$20,231,071 $11.71 65
2020 Q3 20,593,739 $163,306,000 -$36,882,837 $7.93 53
2020 Q2 20,455,938 $373,550,782 +$66,390,720 $18.29 60
2020 Q1 16,827,383 $200,921,119 +$11,941,010 $11.94 46
2019 Q4 15,784,835 $262,061,000 +$1,373,802 $16.64 38
2019 Q3 15,905,791 $105,135,052 +$105,135,052 $6.64 39