| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 14% | +16% | $324,265,066 | +$45,337,554 | 4,907,159 | +16% | FMR LLC | 30 Sep 2025 |
| AI DMI LLC | 8% | -25% | $199,459,837 | -$49,166,626 | 3,018,460 | -20% | AI DMI LLC | 20 Oct 2025 |
| RA CAPITAL MANAGEMENT, L.P. | 5.9% | $177,001,530 | 2,228,924 | RA Capital Management, L.P. | 30 Dec 2025 | |||
| ORBIMED ADVISORS LLC | 4.5% | $73,382,798 | 1,556,369 | ORBIMED ADVISORS LLC | 10 Mar 2025 | |||
| WELLINGTON MANAGEMENT GROUP LLP | 4.1% | -39% | $79,996,547 | -$50,911,307 | 1,432,090 | -39% | Wellington Management Group LLP | 30 Jun 2025 |
| Paradigm Biocapital Advisors LP | 3.5% | $57,097,283 | 1,210,971 | Paradigm BioCapital Advisors LP | 31 Mar 2025 | |||
| Frazier Life Sciences Public Fund, L.P. | 3% | $57,339,676 | 1,026,489 | Frazier Life Sciences Public Fund, L.P. | 30 Jun 2025 | |||
| Bain Capital Life Sciences Opportunities III, LP | 3.3% | $46,372,025 | 983,500 | Bain Capital Life Sciences Opportunities III, LP | 31 Dec 2024 | |||
| Atlas Venture Fund X, L.P. | 2.2% | -30% | $73,469,638 | -$24,517,376 | 813,167 | -25% | Atlas Venture Fund X, L.P. | 12 Dec 2025 |
As of 31 Dec 2025, 191 institutional investors reported holding 38,291,801 shares of Disc Medicine, Inc. - Common Stock, $0.0001 par value per share (IRON). This represents 101% of the company’s total 37,778,373 outstanding shares.
The largest institutional shareholders of Disc Medicine, Inc. - Common Stock, $0.0001 par value per share (IRON) together control 79% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 14% | 5,450,222 | +10% | 0.02% | $432,802,132 |
| BlackRock, Inc. | 6% | 2,274,980 | +13% | 0% | $180,656,161 |
| RA CAPITAL MANAGEMENT, L.P. | 5.2% | 1,976,132 | +25% | 1.6% | $156,924,642 |
| VANGUARD GROUP INC | 4.7% | 1,767,680 | +22% | 0% | $140,371,470 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4.5% | 1,698,005 | +28% | 0.01% | $134,839,000 |
| JPMORGAN CHASE & CO | 4.2% | 1,581,127 | +110% | 0.01% | $125,557,326 |
| WELLINGTON MANAGEMENT GROUP LLP | 4% | 1,518,274 | +7.7% | 0.02% | $120,566,138 |
| Atlas Venture Life Science Advisors, LLC | 4% | 1,513,875 | -29% | 14% | $120,216,814 |
| Frazier Life Sciences Management, L.P. | 3.3% | 1,260,000 | -12% | 2.7% | $100,056,600 |
| STATE STREET CORP | 3.1% | 1,187,991 | +14% | 0% | $94,338,365 |
| ORBIMED ADVISORS LLC | 2.8% | 1,067,550 | -25% | 1.8% | $84,774,146 |
| Siren, L.L.C. | 2.6% | 988,401 | +8.2% | 2.3% | $78,488,923 |
| Woodline Partners LP | 2.5% | 957,833 | +10% | 0.29% | $76,061,519 |
| GOLDMAN SACHS GROUP INC | 2% | 754,195 | +43% | 0.01% | $59,890,625 |
| Vestal Point Capital, LP | 1.9% | 735,000 | +47% | 2.1% | $58,366,350 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.8% | 684,958 | +9% | 0% | $54,402,165 |
| BVF INC/IL | 1.7% | 650,000 | 1.7% | $51,616,500 | |
| JENNISON ASSOCIATES LLC | 1.4% | 532,079 | 0.03% | $42,252,392 | |
| First Light Asset Management, LLC | 1.4% | 523,167 | +126% | 3.2% | $41,544,691 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1.4% | 511,163 | -44% | 0.52% | $40,591,454 |
| Logos Global Management LP | 1.3% | 510,000 | +13% | 2.7% | $40,499,100 |
| ARMISTICE CAPITAL, LLC | 1.3% | 499,391 | +15% | 0.97% | $39,656,639 |
| Checkpoint Capital L.P. | 1.2% | 452,992 | +5.3% | 11% | $35,972,095 |
| PERCEPTIVE ADVISORS LLC | 1.2% | 450,743 | 0.66% | $35,793,502 | |
| EVENTIDE ASSET MANAGEMENT, LLC | 1% | 395,392 | +28% | 0.49% | $31,397,693 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 38,291,801 | $3,040,327,927 | +$327,692,490 | $79.41 | 191 |
| 2025 Q3 | 34,174,573 | $2,258,188,476 | +$16,098,753 | $66.08 | 164 |
| 2025 Q2 | 34,069,403 | $1,804,405,782 | +$52,373,227 | $52.96 | 148 |
| 2025 Q1 | 33,154,047 | $1,649,828,469 | +$313,979,403 | $49.64 | 155 |
| 2024 Q4 | 26,576,603 | $1,684,756,023 | -$53,215,124 | $63.40 | 151 |
| 2024 Q3 | 27,309,249 | $1,342,089,295 | -$26,632,908 | $49.14 | 130 |
| 2024 Q2 | 27,576,793 | $1,242,993,864 | +$212,594,407 | $45.07 | 119 |
| 2024 Q1 | 22,155,328 | $1,379,374,874 | +$124,372,681 | $62.26 | 125 |
| 2023 Q4 | 20,197,167 | $1,166,592,879 | +$18,737,189 | $57.76 | 111 |
| 2023 Q3 | 19,879,838 | $933,957,855 | +$42,877,645 | $46.98 | 90 |
| 2023 Q2 | 19,115,397 | $848,710,699 | +$223,083,623 | $44.40 | 89 |
| 2023 Q1 | 14,612,435 | $309,637,635 | +$77,103,451 | $21.19 | 45 |
| 2022 Q4 | 10,800,037 | $214,639,221 | +$202,496,221 | $19.89 | 30 |