Axsome Therapeutics, Inc. - Common Stock, $0.0001 par value per share (AXSM) Institutional Ownership

13F Institutional Holders and Ownership History from Q4 2015 to Q4 2025

Type / Class
Equity / Common Stock, $0.0001 par value per share
Symbol
AXSM on Nasdaq
Shares outstanding
48,932,355
Price per share
$188.02
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
37,601,715
Total reported value
$6,858,500,942
% of total 13F portfolios
0.02%
Share change
-569,505
Value change
+$24,618,523
Number of holders
392
Price from insider filings
$188.02
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Axsome Therapeutics, Inc. - Common Stock, $0.0001 par value per share (AXSM) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
RTW INVESTMENTS, LP 3.1% -48% $165,312,089 -$153,206,917 1,516,903 -48% RTW Investments, LP 30 Jun 2025

As of 31 Dec 2025, 392 institutional investors reported holding 37,601,715 shares of Axsome Therapeutics, Inc. - Common Stock, $0.0001 par value per share (AXSM). This represents 77% of the company’s total 48,932,355 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of Axsome Therapeutics, Inc. - Common Stock, $0.0001 par value per share (AXSM) together control 51% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
VANGUARD GROUP INC 8.5% 4,164,818 -0.38% 0.01% $760,662,360
BlackRock, Inc. 8% 3,913,543 +3.2% 0.01% $714,769,493
PRICE T ROWE ASSOCIATES INC /MD/ 3.1% 1,509,870 +46% 0.03% $275,763,000
Invesco Ltd. 2.6% 1,273,494 +29% 0.04% $232,590,944
WELLINGTON MANAGEMENT GROUP LLP 2.5% 1,221,656 -8.5% 0.04% $223,123,252
FMR LLC 2.4% 1,181,622 +27% 0.01% $215,811,444
Deep Track Capital, LP 2.4% 1,150,000 +28% 4.8% $210,036,000
GEODE CAPITAL MANAGEMENT, LLC 2.1% 1,010,249 +1.3% 0.01% $184,544,219
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 2% 989,447 0% 0.27% $180,713,000
STATE STREET CORP 2% 958,150 +1.6% 0.01% $174,996,516
RTW INVESTMENTS, LP 1.8% 888,001 -21% 1.6% $162,184,503
ALETHEA CAPITAL MANAGEMENT, LLC 1.4% 668,710 -0.32% 59% $122,133,194
BANK OF AMERICA CORP /DE/ 1.3% 618,033 +71% 0.01% $112,877,457
EVENTIDE ASSET MANAGEMENT, LLC 1.2% 571,226 -23% 1.6% $104,195,166
D. E. Shaw & Co., Inc. 1.1% 549,113 +85% 0.08% $100,289,998
NORGES BANK 1% 495,456 0.01% $90,490,084
MORGAN STANLEY 1% 491,201 +20% 0.01% $89,713,138
Assenagon Asset Management S.A. 0.96% 467,982 +59% 0.13% $85,472,232
Pictet Asset Management Holding SA 0.89% 436,063 +20% 0.08% $79,642,546
CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.82% 402,700 +5.4% 0.01% $73,549,128
NORTHERN TRUST CORP 0.8% 390,431 -4.7% 0.01% $71,308,317
ADAGE CAPITAL PARTNERS GP, L.L.C. 0.75% 367,578 -17% 0.1% $67,134,446
Hood River Capital Management LLC 0.75% 366,176 +1.7% 0.73% $66,878,385
PRINCIPAL FINANCIAL GROUP INC 0.74% 363,114 -1.4% 0.03% $66,319,141
UBS Group AG 0.73% 355,318 +67% 0.01% $64,895,279

Institutional Holders of Axsome Therapeutics, Inc. - Common Stock, $0.0001 par value per share (AXSM) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 37,601,715 $6,858,500,942 +$24,618,523 $182.64 392
2025 Q3 37,169,613 $4,513,412,476 -$67,590,005 $121.45 352
2025 Q2 37,843,872 $3,950,044,159 +$74,087,650 $104.39 345
2025 Q1 36,999,749 $4,315,367,902 +$55,229,563 $116.63 349
2024 Q4 37,175,235 $3,145,106,906 -$176,513,164 $84.61 290
2024 Q3 38,678,079 $3,475,093,026 -$190,434,872 $89.87 277
2024 Q2 40,712,369 $3,277,256,100 +$165,407,783 $80.50 253
2024 Q1 38,735,398 $3,089,970,732 +$16,979,676 $79.80 254
2023 Q4 38,597,370 $3,071,777,083 +$30,855,225 $79.59 242
2023 Q3 37,879,928 $2,647,367,402 +$88,702,381 $69.89 224
2023 Q2 36,371,724 $2,613,474,662 +$329,094,500 $71.86 227
2023 Q1 31,901,760 $1,967,140,427 +$94,141,631 $61.68 194
2022 Q4 30,053,540 $2,317,913,385 +$384,566,478 $77.13 213
2022 Q3 25,705,114 $1,146,849,855 +$196,048,585 $44.62 180
2022 Q2 21,590,557 $826,608,565 +$90,967,881 $38.30 164
2022 Q1 19,105,701 $787,305,601 +$28,307,048 $41.39 165
2021 Q4 18,632,401 $703,886,639 -$18,569,388 $37.78 161
2021 Q3 19,030,753 $625,717,799 -$187,658,523 $32.96 165
2021 Q2 22,332,926 $1,506,651,537 -$37,805,529 $67.46 172
2021 Q1 22,937,308 $1,299,681,826 -$60,738,349 $56.62 181
2020 Q4 23,974,672 $1,951,921,924 -$4,134,242 $81.47 178
2020 Q3 24,031,769 $1,711,934,785 -$21,143,954 $71.25 171
2020 Q2 24,239,746 $1,992,911,051 +$152,460,166 $82.28 188
2020 Q1 22,843,303 $1,344,655,517 +$45,174,721 $58.83 163
2019 Q4 22,285,098 $2,303,381,131 +$375,930,983 $103.36 168
2019 Q3 18,829,417 $381,131,444 +$8,748,444 $20.24 109
2019 Q2 18,265,403 $470,328,087 +$100,449,906 $25.75 107
2019 Q1 14,726,528 $209,555,043 +$159,660,613 $14.23 64
2018 Q4 3,826,666 $10,790,008 +$478,855 $2.82 35
2018 Q3 3,533,711 $12,193,010 -$1,993,489 $3.45 33
2018 Q2 4,098,087 $13,112,972 -$296,661 $3.20 34
2018 Q1 4,234,235 $10,372,895 -$6,125,369 $2.45 35
2017 Q4 5,822,045 $32,606,017 -$1,045,996 $5.60 33
2017 Q3 6,009,091 $33,278,940 -$2,137,110 $5.55 26
2017 Q2 6,403,943 $35,253,289 -$6,146,767 $5.50 34
2017 Q1 7,754,027 $30,238,589 +$7,294,468 $3.90 47
2016 Q4 6,167,172 $41,627,505 -$969,516 $6.75 41
2016 Q3 6,308,290 $49,689,460 +$4,018,404 $7.88 36
2016 Q2 5,799,374 $43,724,574 +$3,925,477 $7.54 34
2016 Q1 5,260,385 $45,240,000 +$313,024 $8.60 17
2015 Q4 5,216,906 $47,654,000 +$47,654,000 $9.25 11