| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 15% | $266,406,847 | 6,907,100 | FMR LLC | 30 Jun 2025 | |||
| Fairmount Funds Management LLC | 10% | 0% | $456,430,807 | +$20,390,674 | 6,047,027 | +4.7% | Peter Evan Harwin | 22 Jan 2026 |
| WELLINGTON MANAGEMENT GROUP LLP | 8.7% | -17% | $374,980,215 | -$10,946,319 | 4,746,585 | -2.8% | Wellington Management Group LLP | 31 Dec 2025 |
| VANGUARD GROUP INC | 5.2% | $215,709,127 | 2,857,824 | The Vanguard Group | 31 Dec 2025 | |||
| RTW INVESTMENTS, LP | 4.9% | -18% | $214,255,663 | 2,712,097 | 0% | RTW Investments, LP | 31 Dec 2025 | |
| BlackRock, Inc. | 5.5% | $109,396,539 | 2,518,725 | BlackRock, Inc. | 30 Jun 2025 | |||
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4.7% | $85,757,284 | 2,158,502 | DRIEHAUS CAPITAL MANAGEMENT LLC | 30 Sep 2025 |
As of 31 Dec 2025, 206 institutional investors reported holding 69,771,331 shares of Apogee Therapeutics, Inc. - Common Stock, $0.00001 par value (APGE). This represents 126% of the company’s total 55,348,918 outstanding shares.
The largest institutional shareholders of Apogee Therapeutics, Inc. - Common Stock, $0.00001 par value (APGE) together control 102% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| VR ADVISER, LLC | 15% | 8,493,321 | 0% | 32% | $641,075,869 |
| FMR LLC | 15% | 8,225,038 | +19% | 0.03% | $620,825,834 |
| WELLINGTON MANAGEMENT GROUP LLP | 8.6% | 4,746,585 | +0.48% | 0.06% | $358,272,236 |
| BlackRock, Inc. | 6.8% | 3,783,994 | +41% | 0% | $285,615,865 |
| VANGUARD GROUP INC | 5.2% | 2,857,824 | +27% | 0% | $215,708,556 |
| T. Rowe Price Investment Management, Inc. | 4.9% | 2,732,456 | +189522% | 0.13% | $206,246,000 |
| RTW INVESTMENTS, LP | 4.9% | 2,712,097 | 0% | 2.1% | $204,709,082 |
| PERCEPTIVE ADVISORS LLC | 4.2% | 2,330,651 | +72% | 3.2% | $175,917,537 |
| Driehaus Capital Management LLC | 3.9% | 2,183,704 | +1.2% | 1.1% | $164,825,978 |
| JANUS HENDERSON GROUP PLC | 3.7% | 2,062,604 | +324% | 0.07% | $155,697,275 |
| Fairmount Funds Management LLC | 3.7% | 2,048,647 | 0% | 12% | $154,631,876 |
| STATE STREET CORP | 3.1% | 1,690,186 | +2.1% | 0% | $127,575,239 |
| JPMORGAN CHASE & CO | 2.5% | 1,373,066 | +21% | 0.01% | $103,639,021 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.2% | 1,237,135 | +65% | 0.01% | $93,380,000 |
| Affinity Asset Advisors, LLC | 2.2% | 1,234,926 | +5.2% | 6.7% | $93,212,214 |
| Paradigm Biocapital Advisors LP | 2% | 1,123,243 | -26% | 2.3% | $84,782,382 |
| ALLIANCEBERNSTEIN L.P. | 2% | 1,093,657 | -23% | 0.03% | $82,549,230 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.9% | 1,059,085 | +19% | 0% | $79,957,396 |
| UBS Group AG | 1.8% | 974,826 | +22% | 0.01% | $73,579,866 |
| MERCER GLOBAL ADVISORS INC /ADV | 1.6% | 890,665 | -8.2% | 0.1% | $67,227,394 |
| MORGAN STANLEY | 1.6% | 890,264 | +91% | 0% | $67,197,243 |
| BANK OF AMERICA CORP /DE/ | 1.4% | 793,695 | +101% | 0% | $59,908,098 |
| CITADEL ADVISORS LLC | 1.4% | 766,981 | -34% | 0.04% | $57,891,726 |
| Remedium Capital Partners, LLC | 1.1% | 583,591 | 0% | 26% | $44,050,000 |
| JENNISON ASSOCIATES LLC | 1% | 578,627 | 0.03% | $43,674,766 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 69,771,331 | $5,266,434,045 | +$762,010,008 | $75.48 | 206 |
| 2025 Q3 | 59,584,020 | $2,367,665,644 | +$56,487,603 | $39.73 | 173 |
| 2025 Q2 | 57,837,483 | $2,511,890,310 | -$147,322,983 | $43.43 | 180 |
| 2025 Q1 | 61,488,037 | $2,301,755,351 | +$131,273,115 | $37.36 | 165 |
| 2024 Q4 | 57,873,775 | $2,621,627,227 | +$63,332,544 | $45.30 | 156 |
| 2024 Q3 | 56,092,373 | $3,292,239,932 | +$134,148,823 | $58.74 | 137 |
| 2024 Q2 | 54,152,101 | $2,130,892,019 | -$9,800,456 | $39.35 | 137 |
| 2024 Q1 | 52,915,146 | $3,516,219,943 | +$778,331,224 | $66.45 | 137 |
| 2023 Q4 | 41,768,396 | $1,163,676,392 | +$48,111,524 | $27.94 | 85 |
| 2023 Q3 | 40,111,211 | $848,653,526 | +$848,653,497 | $21.30 | 73 |