| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 9.9% | $85,778,935 | 15,427,866 | Redmile Group, LLC | 31 Dec 2025 | |||
| Satter Muneer A | 7.2% | $36,032,262 | 10,444,134 | Satter Muneer A | 19 Nov 2025 | |||
| FMR LLC | 7.1% | -30% | $51,316,801 | -$4,310,639 | 10,222,470 | -7.7% | FMR LLC | 31 Dec 2025 |
| BlackRock, Inc. | 6.1% | $44,521,150 | 8,868,755 | BlackRock, Inc. | 31 Dec 2025 | |||
| VANGUARD GROUP INC | 5.3% | +8.2% | $17,797,092 | +$1,389,132 | 5,835,112 | +8.5% | The Vanguard Group | 30 Sep 2025 |
| Bain Capital Life Sciences Fund, L.P. | 4.9% | $9,973,231 | 5,249,069 | BCLS I Investco, LP | 31 Dec 2024 | |||
| Point72 Asset Management, L.P. | 0.1% | $181,317 | 95,430 | Point72 Asset Management, L.P. | 31 Mar 2025 |
As of 31 Dec 2025, 165 institutional investors reported holding 136,863,064 shares of Annexon, Inc. - Common Stock, par value $0.001 per share (ANNX). This represents 88% of the company’s total 155,837,030 outstanding shares.
The largest institutional shareholders of Annexon, Inc. - Common Stock, par value $0.001 per share (ANNX) together control 71% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 6.6% | 10,222,470 | -7.7% | 0% | $51,316,800 |
| Redmile Group, LLC | 6.4% | 10,050,644 | +60% | 3.7% | $50,454,233 |
| BVF INC/IL | 5.9% | 9,128,080 | +30% | 1.5% | $45,822,962 |
| BlackRock, Inc. | 5.7% | 8,960,434 | +13% | 0% | $44,981,380 |
| VANGUARD GROUP INC | 5% | 7,753,387 | +33% | 0% | $38,922,003 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3.5% | 5,500,000 | +267% | 0.04% | $27,610,000 |
| Bain Capital Life Sciences Investors, LLC | 3.4% | 5,249,069 | 0% | 2% | $26,350,326 |
| Bellevue Group AG | 3.3% | 5,157,290 | 0% | 0.49% | $25,889,596 |
| STATE STREET CORP | 3% | 4,652,185 | +127% | 0% | $23,353,969 |
| AMERIPRISE FINANCIAL INC | 2.8% | 4,348,782 | +98% | 0% | $21,830,887 |
| Woodline Partners LP | 2.6% | 4,000,074 | +52% | 0.08% | $20,080,371 |
| Balyasny Asset Management L.P. | 2.1% | 3,299,256 | +154% | 0.03% | $16,562,265 |
| Longaeva Partners L.P. | 2% | 3,100,000 | 1.9% | $15,562,000 | |
| MAK CAPITAL ONE LLC | 1.9% | 2,958,527 | 2% | $14,851,806 | |
| Nuveen, LLC | 1.9% | 2,915,324 | +327% | 0% | $14,634,927 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.9% | 2,902,896 | +19% | 0% | $14,576,148 |
| MORGAN STANLEY | 1.8% | 2,856,143 | -5.7% | 0% | $14,337,838 |
| MILLENNIUM MANAGEMENT LLC | 1.8% | 2,836,857 | +0.5% | 0.01% | $14,241,022 |
| Opaleye Management Inc. | 1.7% | 2,600,000 | 0% | 1.7% | $13,052,000 |
| Palo Alto Investors LP | 1.5% | 2,384,192 | 1.7% | $11,968,644 | |
| Qube Research & Technologies Ltd | 1.5% | 2,381,479 | +316% | 0.02% | $11,955,025 |
| Tetragon Partners GP Ltd | 1.3% | 2,032,455 | -3.8% | 2.2% | $10,202,924 |
| GOLDMAN SACHS GROUP INC | 1.1% | 1,768,745 | -26% | 0% | $8,879,100 |
| BANK OF AMERICA CORP /DE/ | 1% | 1,605,581 | +24% | 0% | $8,060,016 |
| SPHERA FUNDS MANAGEMENT LTD. | 0.84% | 1,316,212 | -27% | 1.4% | $6,607,384 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 136,863,064 | $686,991,189 | +$183,653,760 | $5.02 | 165 |
| 2025 Q3 | 101,393,828 | $309,259,134 | +$11,182,211 | $3.05 | 144 |
| 2025 Q2 | 99,449,067 | $238,679,312 | +$759,672 | $2.40 | 127 |
| 2025 Q1 | 99,491,910 | $192,036,870 | -$14,234,585 | $1.93 | 146 |
| 2024 Q4 | 111,907,572 | $574,088,227 | +$7,286,342 | $5.13 | 151 |
| 2024 Q3 | 109,990,075 | $651,286,147 | +$12,076,588 | $5.92 | 141 |
| 2024 Q2 | 107,381,777 | $526,166,969 | +$50,550,360 | $4.90 | 139 |
| 2024 Q1 | 94,762,361 | $679,439,424 | +$107,931,991 | $7.17 | 125 |
| 2023 Q4 | 80,514,496 | $365,538,892 | +$125,501,716 | $4.54 | 98 |
| 2023 Q3 | 53,312,574 | $125,814,682 | -$910,472 | $2.36 | 91 |
| 2023 Q2 | 53,372,682 | $187,869,879 | -$1,833,578 | $3.52 | 93 |
| 2023 Q1 | 53,953,057 | $207,583,535 | +$11,598,782 | $3.85 | 98 |
| 2022 Q4 | 47,049,561 | $243,269,266 | +$3,854,655 | $5.17 | 81 |
| 2022 Q3 | 46,270,615 | $285,949,000 | +$49,950,788 | $6.18 | 69 |
| 2022 Q2 | 38,409,280 | $144,864,000 | +$5,360,704 | $3.77 | 74 |
| 2022 Q1 | 38,555,259 | $105,261,060 | -$23,763,559 | $2.73 | 96 |
| 2021 Q4 | 38,766,276 | $445,683,894 | +$6,730,750 | $11.49 | 94 |
| 2021 Q3 | 38,055,922 | $708,635,015 | -$28,821,254 | $18.61 | 81 |
| 2021 Q2 | 38,854,536 | $873,668,672 | +$29,687,677 | $22.51 | 73 |
| 2021 Q1 | 37,426,974 | $1,040,768,344 | +$38,809,119 | $27.84 | 72 |
| 2020 Q4 | 36,208,873 | $904,277,496 | -$17,927,945 | $25.03 | 70 |
| 2020 Q3 | 34,842,574 | $1,039,585,431 | +$1,039,585,431 | $30.23 | 65 |