TANG CAPITAL MANAGEMENT LLC - 31 Dec 2025 SCHEDULE 13G/A Report for Spyre Therapeutics, Inc. Common Stock, par value $0.0001 per share (SYRE)

Filing Manager: TANG CAPITAL MANAGEMENT LLC
Reporting Manager: TANG CAPITAL MANAGEMENT, LLC
Security: Spyre Therapeutics, Inc. Common Stock, par value $0.0001 per share
Symbol: SYRE
Shares outstanding: 78,841,667 shares
Disclosed Ownership: 1,892,200 shares
Ownership: 2.4%
Form type: SCHEDULE 13G/A
Filing time: 17 Feb 2026, 16:15:06 UTC
Date of event: 31 Dec 2025
Previous filing: 01 May 2025
SEC: View on sec.gov

Reporting Managers (6)

Name	Ownership	Shares Owned	shared voting power	Signature	Title
TANG CAPITAL MANAGEMENT, LLC	2.4%	1,892,200	1,892,200	/s/ Kevin Tang	Manager
KEVIN TANG	2.4%	1,892,200	1,892,200	/s/ Kevin Tang	Self
TANG CAPITAL PARTNERS, LP	1.3%	1,012,338	1,012,338	/s/ Kevin Tang	Manager, Tang Capital Management, LLC, General Partner
TANG CAPITAL PARTNERS INTERNATIONAL, LP	1.1%	879,862	879,862	/s/ Kevin Tang	Manager, Tang Capital Management, LLC, General Partner
TANG CAPITAL PARTNERS III, INC	0%	0	0	/s/ Kevin Tang	Chief Executive Officer
TANG CAPITAL PARTNERS IV, INC	0%	0	0	/s/ Kevin Tang	Chief Executive Officer