| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 2.8% | 1,417,900 | 0 | 1,417,900 | /s/ Carl L. Gordon | Carl L. Gordon/Member | |
| ORBIMED CAPITAL LLC | 4.9% | 2,422,600 | 2,422,600 | 0 | /s/ Carl L. Gordon | Carl L. Gordon/Member |