Sean Jeffries - 02 Jan 2026 Form 4 Insider Report for Design Therapeutics, Inc. (DSGN)

Role: Chief Operating Officer
Signature: /s/ Mustapha Parekh, Attorney-in-Fact
Issuer symbol: DSGN
Transactions as of: 02 Jan 2026
Net transactions value: $0
Form type: 4
Filing time: 05 Jan 2026, 16:13:01 UTC
Previous filing: 06 Jan 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Jeffries Sean	Chief Operating Officer	C/O DESIGN THERAPEUTICS, INC., 6005 HIDDEN VALLEY ROAD, SUITE 110, CARLSBAD	/s/ Mustapha Parekh, Attorney-in-Fact	05 Jan 2026	0001848377

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	DSGN	Stock option (right to buy)	Award	$0	+375,000		$0.000000	375,000	02 Jan 2026	Common Stock	375,000	$9.10	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The shares subject to the option will vest as follows: 20% of the shares will vest on January 1, 2027, 20% of the shares will vest in equal monthly installments over the following 12 months, 30% of the shares will vest in equal monthly installments over the following 12 months, and 30% of the shares will vest in equal monthly installments over the following 12 months.