| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| ALAM JOHN J | CEO & President, Director, 10%+ Owner | 20 PARK PLAZA, SUITE 424, BOSTON | /s/ William R. Elder, attorney-in-fact for the Reporting Person | 19 Nov 2025 | 0001197014 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | CRVO | Common Stock | Purchase | $91,427 | +10,807 | +0.73% | $8.46 | 1,484,078 | 17 Nov 2025 | Direct | F1, F2, F3 |
| transaction | CRVO | Common Stock | Purchase | $91,309 | +10,793 | +632% | $8.46 | 12,500 | 17 Nov 2025 | Spouse's IRA | F1, F4, F5 |
| Id | Content |
|---|---|
| F1 | Shares purchased in open-market transactions. |
| F2 | The price reported is a weighted average price. The shares were purchased in open-market transactions at prices ranging from $8.39 to $8.46, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full detail regarding the number of shares purchased at each separate price within such range. |
| F3 | Includes (i) 1,471,578 shares held jointly by the Reporting Person and his spouse, Dr. Sylvie Gregoire, PharmD., a member of the Issuer's Board of Directors and (ii) 12,500 shares held by the John J. Alam Roth IRA. |
| F4 | Shares held by the Sylvie Gregoire Roth IRA. |
| F5 | The price reported is a weighted average price. The shares were purchased in open-market transactions at prices ranging from $8.38 to $8.50, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full detail regarding the number of shares purchased at each separate price within such range. |