Christopher Aker - 10 May 2022 Form 4 Insider Report for Regulus Therapeutics Inc. (RGLS)

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	RGLS	Stock Option (Right to Buy)	Award	$0	+70,000		$0.000000	70,000	09 May 2022	Common Stock	70,000	$1.31	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Id	Content
F1	The option vests only upon achievement of a performance-based milestone. The performance criteria were met, resulting in vesting of the option. Upon achievement of the milestone and verification of same by the Company's Compensation Committee, one hundred percent of the shares immediately vested.