| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| 5AM Partners VII, LLC | 34% | -6.7% | $15,119,125 | -$203,807 | 11,541,317 | -1.3% | Andrew J. Schwab | 12 Dec 2025 |
| SPHERA FUNDS MANAGEMENT LTD. | 4.8% | $2,952,706 | 1,476,353 | Sphera Funds Management Ltd. | 31 Mar 2025 | |||
| Schonfeld Strategic Advisors LLC | 3.6% | -32% | $4,441,437 | -$1,996,997 | 1,115,939 | -31% | Schonfeld Strategic Advisors LLC | 30 Jun 2025 |
As of 31 Dec 2025, 49 institutional investors reported holding 16,131,666 shares of Skye Bioscience, Inc. - Common Stock, par value $0.001 (SKYE). This represents 48% of the company’s total 33,945,050 outstanding shares.
The largest institutional shareholders of Skye Bioscience, Inc. - Common Stock, par value $0.001 (SKYE) together control 47% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| 5AM Venture Management, LLC | 29% | 9,681,763 | 0% | 2.3% | $7,258,418 |
| Versant Venture Management, LLC | 5.9% | 2,007,704 | 0% | 1% | $1,505,176 |
| BAKER BROS. ADVISORS LP | 4.3% | 1,450,638 | 0% | 0.01% | $1,087,543 |
| VANGUARD GROUP INC | 2.6% | 882,785 | 0% | 0% | $662,089 |
| SPHERA FUNDS MANAGEMENT LTD. | 1.4% | 478,928 | 0% | 0.08% | $359,052 |
| MILLENNIUM MANAGEMENT LLC | 1.1% | 380,478 | -5.4% | 0% | $285,244 |
| BlackRock, Inc. | 0.83% | 281,841 | +0.71% | 0% | $211,297 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 0.69% | 233,095 | 0% | 0.04% | $174,751 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.62% | 210,151 | +0.74% | 0% | $157,603 |
| Schonfeld Strategic Advisors LLC | 0.28% | 93,407 | -92% | 0% | $70,025 |
| STATE STREET CORP | 0.22% | 75,326 | 0% | 0% | $56,472 |
| XTX Topco Ltd | 0.16% | 53,040 | 0% | $39,764 | |
| TWO SIGMA INVESTMENTS, LP | 0.15% | 51,706 | -44% | 0% | $38,764 |
| TWO SIGMA ADVISERS, LP | 0.12% | 40,982 | 0% | $30,724 | |
| HRT FINANCIAL LP | 0.08% | 27,348 | 0% | $20,000 | |
| JANE STREET GROUP, LLC | 0.07% | 24,615 | +93% | 0% | $18,453 |
| Engineers Gate Manager LP | 0.07% | 23,138 | 0% | $17,347 | |
| GSA CAPITAL PARTNERS LLP | 0.07% | 22,877 | 0% | $17,000 | |
| BARCLAYS PLC | 0.06% | 21,251 | 0% | $15,932 | |
| NORTHERN TRUST CORP | 0.06% | 20,142 | -31% | 0% | $15,100 |
| GROUP ONE TRADING LLC | 0.05% | 17,697 | +634% | 0% | $13,267 |
| R Squared Ltd | 0.04% | 14,782 | 0.01% | $11,082 | |
| UBS Group AG | 0.04% | 13,286 | -56% | 0% | $9,965 |
| CAPITAL ADVISORS INC/OK | 0.03% | 10,000 | 0% | 0% | $7,497 |
| SIMPLEX TRADING, LLC | 0.02% | 6,331 | 0% | $4,746 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 16,131,666 | $12,093,567 | -$11,627,173 | $0.75 | 49 |
| 2025 Q3 | 19,883,163 | $78,141,353 | -$2,101,329 | $3.93 | 56 |
| 2025 Q2 | 20,399,360 | $85,269,369 | -$12,432,557 | $4.18 | 54 |
| 2025 Q1 | 24,700,100 | $39,307,441 | -$1,237,638 | $1.59 | 72 |
| 2024 Q4 | 25,208,315 | $71,310,457 | -$3,219,919 | $2.83 | 70 |
| 2024 Q3 | 25,729,728 | $100,585,169 | +$1,208,054 | $3.91 | 72 |
| 2024 Q2 | 24,496,645 | $196,252,371 | +$179,861,577 | $8.01 | 62 |
| 2024 Q1 | 2,009,303 | $31,404,827 | +$31,400,475 | $15.64 | 3 |
| 2023 Q4 | 1,600 | $4,352 | $2.72 | 1 |