Ensysce Biosciences, Inc. - Common Stock, par value $0.0001 per share (ENSC) Institutional Ownership

13F Institutional Holders and Ownership History from Q4 2024 to Q4 2025

Type / Class
Equity / Common Stock, par value $0.0001 per share
Symbol
ENSC on Nasdaq
Shares outstanding
2,371,778
Price per share
$0.79
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
502,620
Total reported value
$461,118
% of total 13F portfolios
0%
Share change
+126,921
Value change
+$35,780
Number of holders
17
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Ensysce Biosciences, Inc. - Common Stock, par value $0.0001 per share (ENSC) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
PERCEPTIVE ADVISORS LLC 3.7% $264,331 86,666 0% Perceptive Advisors LLC 31 Mar 2025
Adage Capital Management, L.P. 3.2% -43% $167,353 74,711 0% Adage Capital Management, L.P. 30 Jun 2025

As of 31 Dec 2025, 17 institutional investors reported holding 502,620 shares of Ensysce Biosciences, Inc. - Common Stock, par value $0.0001 per share (ENSC). This represents 21% of the company’s total 2,371,778 outstanding shares.

Top 22 Institutional Shareholders

The largest institutional shareholders of Ensysce Biosciences, Inc. - Common Stock, par value $0.0001 per share (ENSC) together control 21% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
ADAGE CAPITAL PARTNERS GP, L.L.C. 6.3% 149,711 +100% 0% $137,734
DRW Securities, LLC 4.2% 98,481 +42% 0.01% $90,602
PERCEPTIVE ADVISORS LLC 3.7% 86,666 0% 0% $79,733
VANGUARD GROUP INC 1.5% 36,708 0% 0% $33,772
HRT FINANCIAL LP 1% 24,491 0% $22,000
Financial Plan, Inc. 1% 24,000 0% 0% $22,080
GEODE CAPITAL MANAGEMENT, LLC 0.93% 22,090 +70% 0% $20,322
TWO SIGMA SECURITIES, LLC 0.91% 21,605 0% $19,877
Williams & Novak, LLC 0.75% 17,850 0.01% $16,422
TRU INDEPENDENCE ASSET MANAGEMENT 2, LLC 0.51% 12,000 +14% 0.01% $11,040
Tower Research Capital LLC (TRC) 0.22% 5,319 +295% 0% $4,893
FNY Investment Advisers, LLC 0.13% 3,000 0% 0% $2,000
SBI Securities Co., Ltd. 0.02% 421 +0.72% 0% $387
UBS Group AG 0% 100 -88% 0% $92
BANK OF AMERICA CORP /DE/ 0% 72 +200% 0% $66
BlackRock, Inc. 0% 65 0% 0% $60
JONES FINANCIAL COMPANIES LLLP 0% 41 0% $38
RENAISSANCE TECHNOLOGIES LLC 0% 0 -100% $0
CITADEL ADVISORS LLC 0% 0 -100% $0
ASSETMARK, INC 0% 0 -100% $0
XTX Topco Ltd 0% 0 -100% $0
Virtu Financial LLC 0% 0 -100% $0

Institutional Holders of Ensysce Biosciences, Inc. - Common Stock, par value $0.0001 per share (ENSC) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 502,620 $461,118 +$35,780 $0.92 17
2025 Q3 351,699 $833,709 +$409,291 $2.37 17
2025 Q2 179,153 $398,820 -$449,714 $2.23 11
2025 Q1 353,153 $903,390 +$543,275 $2.56 9
2024 Q4 140,823 $1,145,879 +$1,145,879 $8.14 8