AYTU BIOPHARMA, INC - Common Stock (AYTU) Institutional Ownership

13F Institutional Holders and Ownership History from Q1 2023 to Q4 2025

Type / Class
Equity / Common Stock
Symbol
AYTU on Nasdaq
Shares outstanding
10,724,234
Price per share
$2.62
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
3,771,496
Total reported value
$9,805,147
% of total 13F portfolios
0%
Share change
+181,243
Value change
+$483,628
Number of holders
37
Price from insider filings
$2.62
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of AYTU BIOPHARMA, INC - Common Stock (AYTU) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
Nantahala Capital Management, LLC 14% $1,423,724 1,086,812 Nantahala Capital Management, LLC 06 Jun 2025
LYTTON LAURENCE W 10% 0% $2,828,367 -$40,051 1,071,351 -1.4% LYTTON LAURENCE W 31 Dec 2025
Stonepine Capital Management, LLC 9.9% $1,975,217 906,063 Stonepine Capital Management, LLC 30 Jun 2025

As of 31 Dec 2025, 37 institutional investors reported holding 3,771,496 shares of AYTU BIOPHARMA, INC - Common Stock (AYTU). This represents 35% of the company’s total 10,724,234 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of AYTU BIOPHARMA, INC - Common Stock (AYTU) together control 35% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
Nantahala Capital Management, LLC 10% 1,086,812 0% 0.17% $2,825,711
Stonepine Capital Management, LLC 7.6% 813,704 -8.8% 1.7% $2,115,630
AWM Investment Company, Inc. 5.8% 619,574 0% 0.16% $1,610,892
DIADEMA PARTNERS LP 2.9% 305,788 +12% 0.47% $795,049
VANGUARD GROUP INC 2.6% 278,583 0% 0% $724,316
TWO SIGMA INVESTMENTS, LP 1% 107,133 +56% 0% $278,546
RENAISSANCE TECHNOLOGIES LLC 0.84% 89,623 -5.8% 0% $233,020
Persistent Asset Partners Ltd 0.74% 79,415 +27% 0.1% $206,479
GEODE CAPITAL MANAGEMENT, LLC 0.69% 74,097 +4.4% 0% $192,685
TWO SIGMA ADVISERS, LP 0.4% 42,500 +6.8% 0% $110,500
DIMENSIONAL FUND ADVISORS LP 0.33% 35,363 +14% 0% $91,944
FNY Investment Advisers, LLC 0.29% 31,600 0.02% $82,000
DRW Securities, LLC 0.27% 29,368 0.01% $76,356
XTX Topco Ltd 0.24% 25,860 0% $67,236
BELLEVUE ASSET MANAGEMENT, LLC 0.23% 25,013 0.03% $65,033
BlackRock, Inc. 0.21% 22,793 0% 0% $59,262
Rothschild Wealth LLC 0.19% 20,000 0% $52,000
Perritt Capital Management Inc 0.19% 20,000 0.09% $52,000
NORTHERN TRUST CORP 0.18% 19,169 0% $49,839
CITADEL ADVISORS LLC 0.15% 15,551 0% $40,433
ACADIAN ASSET MANAGEMENT LLC 0.1% 10,237 0% 0% $26,000
Daytona Street Capital LLC 0.09% 10,000 0% 0.02% $26,000
MAI Capital Management 0.03% 3,575 0% 0% $9,295
UBS Group AG 0.03% 3,049 -2.7% 0% $7,927
Tower Research Capital LLC (TRC) 0.02% 1,713 -60% 0% $4,454

Institutional Holders of AYTU BIOPHARMA, INC - Common Stock (AYTU) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 3,771,496 $9,805,147 +$483,628 $2.60 37
2025 Q3 3,580,253 $6,730,606 +$120,541 $1.88 31
2025 Q2 3,416,181 $7,446,105 +$3,456,447 $2.18 30
2025 Q1 1,876,606 $2,489,917 +$8,023 $1.20 29
2024 Q4 1,880,741 $3,193,340 -$294,695 $1.70 28
2024 Q3 2,048,299 $4,813,170 -$27,368 $2.35 23
2024 Q2 2,053,775 $5,994,953 +$752,481 $2.92 26
2024 Q1 1,795,464 $5,457,735 +$79,751 $3.04 26
2023 Q4 1,769,256 $5,024,294 +$125,688 $2.84 21
2023 Q3 1,724,718 $4,655,967 +$78,103 $2.70 20
2023 Q2 1,704,120 $2,726,370 +$1,773,284 $1.60 19
2023 Q1 540,753 $1,211,630 +$1,211,205 $2.24 18